巨细胞病毒感染对胆总管囊肿儿童肝功及预后的影响  

Effects of cytomegalovirus infection on liver function and prognosis of children with choledochal cyst

作　　者：张生[1] ZHANG Sheng(Xi'an Children's Hospital,Xi'an 710003,China)

机构地区：[1]西安市儿童医院,陕西西安710003

出　　处：《临床医学研究与实践》2021年第32期46-48,共3页Clinical Research and Practice

基　　金：西安市卫生局课题(No.J2014029)。

摘　　要：目的探讨巨细胞病毒感染对胆总管囊肿儿童肝功及预后的影响。方法选取西安市儿童医院2019年1月1日至2020年1月1日收治的58例行腹腔镜手术治疗的胆总管囊肿患儿,根据血巨细胞病毒PCR的检测结果是否为阳性将其分为病毒感染组(巨细胞病毒DNA阳性,26例)与非病毒感染组(巨细胞病毒DNA阴性,32例)。分别于术前、术后第3天检测两组患儿的肝功能指标(TBIL、ALT、AST),统计手术时间、术中出血量、住院天数、术中胆管穿孔率及术后并发症发生情况。结果术前、术后第3天,病毒感染组的TBIL、ALT、AST水平均高于非病毒感染组(P<0.05)。病毒感染组手术时间及住院天数长于非病毒感染组,术中出血量多于非病毒感染组(P<0.05)。病毒感染组术中胆管穿孔率及术后并发症总发生率均高于非病毒感染组(P<0.05)。结论胆总管囊肿患儿容易合并巨细胞病毒感染,且感染后肝损害明显加重,手术难度明显增加,术后恢复较慢,并发症发生率也较高。Objective To explore the effects of cytomegalovirus infection on liver function and prognosis of children with choledochal cyst.Methods A total of 58 choledochal cyst children underwent laparoscopic surgery admitted in Xi'an children's hospital from January 1,2019 to January 1,2020 were selected.The children were divided into virus infection group(cytomegalovirus DNA positive,26 cases)and non-virus infection group(cytomegalovirus DNA negative,32 cases)according to whether cytomegalovirus PCR results were positive or not.Liver function indexes(TBIL,ALT,AST)of the two groups were detected before the operation and at the 3rd d of postoperation,respectively,and the operative time,intraoperative blood loss volume,length of hospital stay,intraoperative bile duct perforation rate and postoperative complications were counted.Results Before the operation and at the 3rd d of postoperation,the levels of TBIL,ALT and AST in the virus infection group were higher than those in the non-virus infection group(P<0.05).The operation time and length of hospital stay in the virus infection group were longer than those in the non-virus infection group,and the intraoperative blood loss volume was more than that in the non-virus infection group(P<0.05).The rate of intraoperative bile duct perforation and the total incidence of postoperative complications in the virus infection group were higher than those in the non-virus infection group(P<0.05).Conclusion Children with choledochal cyst are easy to be complicated with cytomegalovirus infection,and the liver damage after infection is significantly aggravated,the difficulty of operation is significantly increased,postoperative recovery is slower,and the incidence of complications is higher.

关 键 词：胆总管囊肿 巨细胞病毒 腹腔镜 肝功能 

分 类 号：R725.7[医药卫生—儿科]