Termitomenins F and G,Two New Lignan Glucosides from Terminalia chebula var.tomentella(Kurz)C.B.Clarke  

作　　者：Jun Yin Hong‑Tao Zhu Man Zhang Dong Wang Chong‑Ren Yang Ying‑Jun Zhang 

机构地区：[1]State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650201,People’s Republic of China [2]University of Chinese Academy of Sciences,Beijing 100049,People’s Republic of China [3]Yunnan Key Laboratory of Natural Medicinal Chemistry,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650201,People’s Republic of China

出　　处：《Natural Products and Bioprospecting》2021年第5期565-572,共8页应用天然产物（英文）

摘　　要：The extensive chemical investigation on the branches and leaves of Terminalia chebula var.tomentella(Combretaceae)led to the isolation of two new lignan glucosides with a furofuran skeleton,termitomenins F(1)and G(2).In addition,19 known compounds including five lignan glucosides(3-7),six hydrolyzable tannins(8-13)and eight simple phenolics(14-21)were also identified.Their structures were determined by comprehensive spectroscopic analyses.It is noted that 8 and 9 were C-glycosidic hydrolyzable tannins with one hexahydroxydiphenoyl and one gallagyl group linked to an open-chain glucosyl C-1/O-2/O-3 and O-4/O-6,respectively,which were rarely found in plants.Nine known compounds,6-9,13,and 18-21,were procured from the titled plant for the first time,while 3-5,10-12 and 14-17 were also found in the fruits.Notably,the known hydrolyzable tannins 8-13 exhibited strongerα-glucosidase inhibitory activities with IC_(50) values ranging from 0.10 to 3.12μM,than the positive control,quercetin(IC_(50)=9.38±0.33μM).

关 键 词：Terminalia chebula var.tomentella Lignan glucosides Hydrolyzable tannins α-Glucosidase inhibitory activity Calculated ECD 

分 类 号：R284[医药卫生—中药学]