经皮冠状动脉介入治疗后患者血清长链非编码RNA GAS5水平与冠状动脉支架内再狭窄的相关性  

Correlation of serum long-chain non-coding RNA GAS5 level and coronary restenosis in patients after percutaneous coronary intervention

作　　者：陈晓杰[1] 梁春玲[1] 于洁[2] 谢宇端 CHEN Xiaojie;LIANG Chunling;YU Jie;XIE Yuduan(Intervention Center of Emergency Department,Chinese Academy of Traditional Chinese Medicine,Beijing 100102,China;Department of Cardiology,Chinese Academy of Traditional Chinese Medicine,Beijing 100102,China;Laboratory,Wangjing Hospital,Chinese Academy of Traditional Chinese Medicine,Beijing 100102,China)

机构地区：[1]中国中医科学院望京医院急诊科介入诊疗中心,北京市100102 [2]中国中医科学院望京医院心内科,北京市100102 [3]中国中医科学院望京医院检验科,北京市100102

出　　处：《中国动脉硬化杂志》2021年第12期1066-1070,共5页Chinese Journal of Arteriosclerosis

基　　金：北京中医药科技发展资金项目(JJ2018-93);中国中医科学院望京医院科研课题(WJYY2018-09)。

摘　　要：目的探究血清长链非编码RNA GAS5(lncRNA GAS5)水平与急性ST段抬高型心肌梗死(STEMI)患者冠状动脉支架内再狭窄的相关性。方法选取接受择期经皮冠状动脉介入治疗(PCI)的STEMI患者144例,根据随访结果将患者分为支架内再狭窄(ISR)组27例和非ISR组109例,失访8例。收集STEMI患者临床资料。采用实时荧光定量PCR(qRT-PCR)检测所有患者PCI术后血清lncRNA GAS5水平。结果与非ISR组相比,ISR组患者术前吸烟及合并糖尿病比例、总胆红素(TBIL)、血清总胆固醇(TC)、低密度脂蛋白胆固醇(LDLC)水平较高(P<0.05),血清中lncRNA GAS5水平较低(P<0.05);与lncRNA GAS5高水平者相比,lncRNA GAS5低水平者ISR发生率较高(P<0.05),无再狭窄平均时间较短(P<0.05);Logistic回归分析显示,低水平lncRNA GAS5是STEMI患者冠状动脉支架内再狭窄的危险因素。结论lncRNA GAS5在STEMI冠状动脉支架内再狭窄患者血清中水平下调,低水平lncRNA GAS5是STEMI患者冠状动脉支架内再狭窄的危险因素。Aim To investigate the correlation between serum long-chain non-coding RNA GAS5(lncRNA GAS5)level and in-stent restenosis in patients with acute ST-segment elevation myocardial infarction(STEMI).Methods 144 patients with STEMI who received selective percutaneous coronary intervention were selected,and according to the follow-up results,the patients were divided into 27 cases of in-stent restenosis(ISR)group and 109 cases of non-ISR group,with 8 cases lost.The clinical data of patients with STEMI were collected.The level of serum lncRNA GAS5 in all patients after percutaneous coronary intervention was measured by real-time quantitative PCR(qRTPCR).Results Compared with non-ISR group,the proportions of smokers before operation and complicated diabetic,total bilirubin(TBIL),levels of total cholesterol(TC)and low density lipoprotein cholesterol(LDLC)in serum in ISR group were increased(P<0.05),and the level of lncRNA GAS5 in serum was decreased(P<0.05);The incidence of ISI in low level of GAS5 was higher than that in the patients with high level of lncRNA GAS5(P<0.05),and the average time of no restenosis was shorter(P<0.05);Logistic regression analysis showed that low level of lncRNA GAS5 was a risk factor of in-stent restenosis in patients with STEMI.Conclusion The level of lncRNA GAS5 is down-regulated in the serum of in-stent restenosis patients with STEMI,and it is a risk factor of in-stent restenosis patients with STEMI.

关 键 词：急性ST段抬高型心肌梗死 经皮冠状动脉介入治疗 支架内再狭窄 长链非编码RNA GAS5 

分 类 号：R5[医药卫生—内科学]