细胞代谢因子Betatrophin脂质调控研究进展  

Research progress of Betatrophin lipid regulation

作　　者：秦练 马翔[1] 王忠[2] 杜怡颖 张丹 QIN Lian;MA Xiang;WANG Zhong;DU Yiying;ZHANG Dan(Heart Center of the First Affiliated Hospital of Xinjiang Medical University,Urumqi,Xinjiang Uygur Autonomous Region 830054,China;Department of Cardiology,The First Affiliated Hospital of Shihezi University School of Medicine,Shihezi,Xinjiang Uygur Autonomous Region 832008,China)

机构地区：[1]新疆医科大学第一附属医院心脏中心,新疆维吾尔自治区乌鲁木齐市830054 [2]石河子大学医学院第一附属医院心内二科,新疆维吾尔自治区石河子市832008

出　　处：《中国动脉硬化杂志》2021年第12期1085-1088,共4页Chinese Journal of Arteriosclerosis

基　　金：国家自然科学基金(地区科学基金项目)(8660085)。

摘　　要：细胞代谢因子Betatrophin,也被命名为胰岛生成激素或血管生成素样蛋白8,主要在人体肝脏及脂肪组织中表达。越来越多的证据表明细胞代谢因子Betatrophin的表达与血脂水平之间存在关联,特别是在肥胖或糖尿病患者中,在胰岛素、甲状腺激素及能量摄入等因素刺激下均能够导致Betatrophin水平增加。在动物模型中亦验证了细胞代谢因子Betatrophin可导致血清甘油三酯水平升高,以及促进胰腺β细胞增殖。本文综述了Betatrophin在脂质调控中的最新研究进展。Betatrophin,also known as lipasin or angiopoietin-like protein 8(ANGP TL8),is mainly expressed in human liver and adipose tissue.There is increasing evidence to show the correlation between betatrophin expression and blood lipid levels,and especially in patients of obesity or diabetes,stimulated by factors such as insulin,thyroid hormone,and energy intake,it can lead to an increase in betatrophin levels.It has also been verified in animal models that betatrophin can increase serum triglyceride levels and promote the proliferation of pancreaticβ-cells.This article reviews the latest research progress of betatrophin in lipid regulation.

关 键 词：细胞代谢因子 脂质代谢 调控机制 

分 类 号：R5[医药卫生—内科学]