全麻诱导期间不同用药顺序对注射痛和呛咳的影响  

The Effect of the Various Turns of Application of the Drugs on the Injection Pain and Coughing during the Induction of General Anesthesia

作　　者：王荣宁[1] 陈鑫 姚吉祥 苏珊珊 WANG Rongning;CHEN Xin;YAO Jixiang;SU Shanshan(Department of Anesthesiology,Taizhou City People's Hospital,Taizhou 225300,China)

机构地区：[1]江苏省泰州市人民医院麻醉科,泰州225300

出　　处：《宁夏医科大学学报》2021年第10期1069-1072,共4页Journal of Ningxia Medical University

摘　　要：目的观察全麻诱导中,不同药物(舒芬太尼、丙泊酚、罗库溴铵)的使用顺序对药物所致注射痛和呛咳的影响。方法将择期行腹腔镜下胆囊切除术(LC)的180例患者,随机均分为三组:舒芬太尼、丙泊酚、罗库溴铵依次使用组(T_(1)组)、丙泊酚、舒芬太尼、罗库溴铵依次使用组(T_(2)组)、丙泊酚、罗库溴铵、舒芬太尼依次使用组(T_(3)组)。全麻诱导时,各组按各自顺次使用药物。记录各组注射痛(丙泊酚、罗库溴铵致)及呛咳(舒芬太尼致)的发生情况。结果T_(1)组患者注射痛(丙泊酚致)发生率均低于T_(2)组、T_(3)组(P均<0.001);T_(3)组患者注射痛(罗库溴铵致)发生率均高于T_(1)组、T_(2)组(P均<0.001);T_(1)组患者总注射痛发生率低于T_(2)组、T_(3)组(P均<0.01),T_(2)组患者总注射痛发生率低于T_(3)组(P<0.01)。T_(1)组、T_(2)组患者呛咳发生率高于T_(3)组(P均<0.05)。结论全麻诱导中,较早地使用阿片类药物,能有效降低相关药物(丙泊酚、罗库溴铵)所致注射痛的发生风险,且呛咳(舒芬太尼所致)发生率并未增加。Objective To observe the effect of various turns of application of the drugs(sufentanil,propofol and rocuronium)on the injection pain(propofol and rocuronium-induced)and coughing(sufentanil-induced)during the induction of general anesthesia.Methods One hundred and eighty patients undergoing laparoscopic cholecystectomy(LC)were randomly divided into group T_(1)(by turns of sufentanil,propofol and rocuronium),group T_(2)(by turns of propofol,sufentanil and rocuronium)and group T_(3)(by turns of propofol,rocuronium and sufentanil).During the induction of general anesthesia,drugs were injected in three groups by their individual turns.The incidence of the injection pain(propofol and rocuronium-induced)and the coughing(sufentanil-induced)were recorded.Results The incidence of the injection pain(propofol-induced)in group T_(1) was lower than that in group T_(2) and in group T_(3)(P all<0.001);The incidence of the injection pain(rocuronium-induced)in group T_(3) was higher than that in group T_(1) and in group T_(2)(P all<0.001);The incidence of the injection pain(total,propofol and rocuronium-induced)in group T_(1) was lower than that in group T_(2) and in group T_(3)(P all<0.01);The incidence of the injection pain(total,propofol and rocuronium-induced)in group T_(2) was lower than that in group T_(3)(P<0.01);The incidence of the coughing in group T_(1) and in group T_(2) was higher than that in group T_(3)(P all<0.05).Conclusion During the induction of general anesthesia,the earlier application of opioid could effectively reduce the incidence of the injection pain(propofol and rocuronium-induced),and could not increase the incidence of the coughing significantly(sufentanil-induced).

关 键 词：注射痛 呛咳 顺序 阿片类 全麻 

分 类 号：R614.2[医药卫生—麻醉学]