双歧杆菌三联活菌胶囊辅助治疗对2型糖尿病患者血糖波动及脂质过氧化损伤的影响  

Effect of adjuvant therapy of Bifidobacterium Triple Viable capsules on blood glucose fluctuation and lipid peroxidation damage in patients with type 2 diabetes

作　　者：李亮 王君福 LI Liang;WANG Jun-fu(Medical Department,Taizhou Cancer Hospital of Zhejiang Province,Taizhou,Zhejiang 317502,China;不详)

机构地区：[1]台州市肿瘤医院内科,浙江317502 [2]台州市肿瘤医院检验科

出　　处：《中国微生态学杂志》2021年第9期1070-1072,1081,共4页Chinese Journal of Microecology

摘　　要：目的探讨双歧杆菌三联活菌胶囊辅助治疗对2型糖尿病(T2DM)患者血糖波动及脂质过氧化损伤的影响,为该类患者的治疗提供参考。方法选取2019年1月至8月我院内科门诊治疗的84例T2DM患者,随机分为观察组和对照组各42例。两组患者均给予饮食控制和适当运动锻炼等基础治疗。对照组患者给予甘精胰岛素与阿卡波糖控制血糖。观察组患者在对照组基础加用双歧杆菌三联活菌胶囊630 mg/次,2次/d,温开水服用。两组患者连用12周。观察两组患者治疗前后血糖波动指标[日平均血糖波动幅度(MAGE)、血糖标准差(SDBG)和最大血糖波动幅度(LAGE)]及脂质过氧化指标[谷胱甘肽过氧化物酶(GSH-PX)、脂质过氧化氢(LHP)、活性氧类物质(ROS)和总抗氧化能力(T-AOC)]水平的变化。结果治疗12周后,两组患者血清MAGE、SDBG和LAGE水平较治疗前明显下降,且观察组下降幅度大于对照组(均P<0.05);同时两组患者血清GSH-PX和T-AOC水平较治疗前显著上升,血清LHP和ROS水平均较治疗前显著下降,且观察组变化幅度大于对照组(均P<0.05)。结论双歧杆菌三联活菌胶囊辅助治疗T2DM患者可改善其糖代谢指标水平,减少血糖波动程度,机制可能与其能减轻脂质过氧化损伤相关。Objective To observe the effect of adjuvant therapy of Bifidobacterium Triple Viable capsules on blood glucose fluctuation and lipid peroxidation damage in patients with type 2 diabetes(T2 DM) and provide a reference for the treatment. Methods A total of 84 T2 DM patients treated in our hospital from January 2019 to August 2019 were randomly divided into observation group or control group, 42 cases each. The patients in both groups were given basic treatments such as diet control and proper exercise. In addition, the patients in control group received insulin glargine and acarbose to control blood glucose, while those in observation group received Bifidobacterium Triple Viable capsules 630 mg bid. All the patients were treated for 12 weeks. The blood glucose fluctuation indicators [daily mean blood glucose fluctuation range(MAGE), blood glucose standard deviation(SDBG), and maximum blood glucose fluctuation range(LAGE)] and lipid peroxidation damage indicators [glutathione peroxidase(GSH-PX), lipid hydrogen peroxide(LHP), reactive oxygen species(ROS) and total antioxidant capacity(T-AOC)] were observed before and after treatment. Results After treatment, the serum levels of MAGE, SDBG and LAG in both groups were significantly lower and the decline in observation group was more significant than that in control group(all P<0.05);The serum GSH-PX and T-AOC in both groups increased significantly while the serum LHP and ROS decreased significantly, and the changes in observation group were more significant than those in control group(all P<0.05). Conclusion Bifidobacterium triple viable capsules can improve glucose metabolism indexes and reduce blood sugar fluctuations in T2 DM patients. The mechanism may be closely related to its potential to reduce lipid peroxidation damage.

关 键 词：2型糖尿病 双歧杆菌三联活菌胶囊 血糖波动 脂质过氧化损伤 

分 类 号：R378[医药卫生—病原生物学]