肠道菌群失调与肝硬化伴SBP患者疾病发展的关系及三联活菌胶囊干预性研究  

Relationship between intestinal flora imbalance and disease development in patients with liver cirrhosis with SBP and intervention with triple viable capsule

作　　者：刘丽波[1] 王淑辉 段旭峰 孔学哲 张保茹 冯军[2] 杨婷[1] 李慧[1] LIU Li-bo;WANG Shu-hui;DUAN Xu-feng;KONG Xue-zhe;ZHANG Bao-ru;FENG Jun;YANG Ting;LI Hui(Gastroenterology,No.981 Hospital of Chinese People′s Liberation Army Joint Logistics Support Force,Chengde,Hebei 067000,China;不详)

机构地区：[1]中国人民解放军联勤保障部队第九八一医院消化内科,河北承德067000 [2]河北省承德市中心医院检验科,河北承德067000

出　　处：《中国微生态学杂志》2021年第9期1086-1089,共4页Chinese Journal of Microecology

摘　　要：目的分析肠道菌群失调与肝硬化伴自发性细菌性腹膜炎(SBP)患者疾病发展的关系及三联活菌胶囊的应用价值。方法将我院2017年1月至2019年12月间收治的94例肝硬化伴SBP患者作为观察组研究对象,50例健康者作为本研究对照组,将观察组患者依照随机信封法分为B组及A组,B组采用三联活菌胶囊治疗,A组采用常规方案治疗。采用16S rDNA测序技术检测患者肠道菌群种类和多样性。结果观察组患者诺卡氏菌科、盐单胞菌科、肠杆菌科、链球菌科、韦荣球菌科丰度均高于对照组,拟杆菌科、普雷沃菌科、毛螺菌科均低于对照组,OTUs、Chao、Shannon指数明显低于对照组。肠道菌群种类、OTUs、Chao、Shannon指数是影响肝硬化伴SBP患者疾病发展的影响因素,以上差异均就有统计学意义(P<0.05)。治疗后B组患者肠道菌群OTUs、Chao和Shannon明显高于对照组,差异均具有统计学意义(P<0.05)。结论肠道菌群失调是影响肝硬化伴SBP患者疾病发展的独立影响因素,采用三联活菌胶囊干预可有效纠正患者体内肠道菌群失调。Objective To analyze the relationship between intestinal flora imbalance and disease development in patients with liver cirrhosis with spontaneous bacterial peritonitis, and the application value of triple viable capsule. Methods Ninety-four patients with liver cirrhosis and SBP treated in our hospital from January 2017 to December 2019 were enrolled as the observation group, with 50 healthy individuals as the control group. The patients in the observation group were randomly divided into group B(triple viable capsule) or group A(conventional protocols). 16 S rDNA sequencing technology was used to detect the type and diversity of intestinal flora. Results The counts of Nocardiaceae, Halomonadaceae, Enterobacteriaceae, Streptococci and Veillonella were significantly higher, while those of Bacteroidaceae, Prevotellaceae and Lachnospiraceae were lower in observation group than in control group, respectively(all P<0.05). Intestinal flora species, OTUs, Chao, and Shannon index were independent factors that affect the disease development of patients with liver cirrhosis and SBP(P<0.05). The types of intestinal flora in group B were significantly better than in group A after treatment(P<0.05). The levels of OTUs, Chao and Shannon in group B patients were significantly superior than those in the control group after treatment(P<0.05). Conclusions Intestinal flora imbalance is an independent factor that affects the development of disease in patients with liver cirrhosis and SBP. Intervention with triple viable capsule can effectively correct the intestinal flora imbalance in the patients.

关 键 词：肠道菌群失调 肝硬化伴SBP 三联活菌胶囊 

分 类 号：R657.3[医药卫生—外科学]