桂西地区壮族人群亚甲基四氢叶酸还原酶基因C677T多态性与MS的相关性  

Correlation between methylenetetrahydrofolate reductase C677T polymorphism and metabolic syndrome in Zhuang population of west Guangxi

作　　者：梁庆祝 李晓蕾 潘海林[2] 邓富鸿 黄椿楣 韦必晓 陈秀林 谷梅金 Liang Qingzhu;Li Xiaolei;Pan Hailin;Deng Fuhong;Huang Chunmei;Wei Bixiao;Chen Xiulin;Gu Meijin(People’s Hospital of Baise,Southwest Hospital Affiliated to Youjiang Medical University for Nationalities,Baise 533000,Guangxi,China;Department of Endocrinology,The Second Affiliated Hospital of Guangxi Medical University,Nanning 530000,Guangxi,China)

机构地区：[1]广西百色市人民医院,右江民族医学院附属西南医院,广西百色533000 [2]广西医科大学第二附属医院内分泌科,广西南宁530000

出　　处：《右江民族医学院学报》2021年第5期627-631,共5页Journal of Youjiang Medical University for Nationalities

基　　金：广西百色市科技计划项目(自筹经费)(百科20202811)。

摘　　要：目的探讨桂西地区壮族人群亚甲基四氢叶酸还原酶(MTHFR)基因C677T多态性与代谢综合征(MS)的相关性。方法选取壮族MS组362例、汉族MS组318例、壮族健康对照组565例,作为研究对象。收集各组的临床资料(年龄、血压、腹围等)和生化指标[血糖、总胆固醇、甘油三酯、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、同型半胱氨酸等],采用PCR-RFL检测MTHFR基因C677T多态性,比较各组的临床资料、生化指标,分析不同基因型与MS的相关性。结果壮族MS组年龄、腰围、空腹血糖、收缩压、舒张压、甘油三酯、HDL-C、LDL-C、总胆固醇、同型半胱氨酸均值与壮族健康对照组相比,差异有统计学意义(P<0.05)。壮族MS组与壮族健康对照组基因型和等位基因分布的差异有统计学意义(χ2=19.233,P<0.05;χ2=16.195,P<0.05)。Logistic回归分析结果显示年龄(OR=1.035,95%CI:1.023~1.047)、高浓度的同型半胱氨酸(OR=1.030,95%CI:1.001~1.060)、T等位基因(OR=1.492,95%CI:1.172~1.900)是MS的危险因素。结论桂西地区壮族人群MTHFR基因C677T多态性与MS相关。Objective To explore the correlation between methylenetetrahydrofolate reductase(MTHFR)C677T polymorphism and metabolic syndrome(MS)in Zhuang population in west Guangxi.Methods The subjects were selected and divided into Zhuang MS group(n=362),Han MS group(n=318)and Zhuang healthy control group(n=565).Their clinical data(age,blood pressure,abdominal circumference,etc.)and biochemical indexes[blood glucose,total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C),homocysteine(Hcy),etc.]were collected,and their MTHFR C677T polymorphism were detected by PCR-RFL.The clinical data and biochemical indexes were compared among three groups.The correlations of different genotypes with MS were analyzed.Results There were significant differences in the mean values of age,waist circumference,fasting blood glucose(FBG),systolic blood pressure(SBP),diastolic blood pressure(DBP),TG,HDL-C,LDL-C,TC and Hcy between Zhuang MS group and Zhuang healthy control group(P<0.05).There were significant differences in the genotypes and allele distributions between Zhuang healthy control group and Zhuang MS group(χ2=19.233,P<0.05;χ2=16.195,P<0.05).Logistic regression analysis showed that age(OR=1.035,95%CI:1.023~1.047),high concentration of Hcy(OR=1.030,95%CI:1.001~1.060)and T allele(OR=1.492,95%CI:1.172~1.900)were the risk factors of MS.Conclusion The MTHFR C677T polymorphism in Zhuang population in west Guangxi is associated with MS.

关 键 词：代谢综合征 亚甲基四氢叶酸还原酶 基因C677T多态性 桂西地区壮族人群 

分 类 号：R58[医药卫生—内分泌]