淫羊藿活性单体成分调控骨质疏松症相关信号通路影响骨吸收与骨形成的稳态  

Active monomer composition of Epimedium influences the homeostasis of bone resorption and bone formation by regulating osteoporosis related signaling pathways

作　　者：李时斌 夏天[2] 章晓云[1] 王伟伟 周毅 赖渝 Li Shibin;Xia Tian;Zhang Xiaoyun;Wang Weiwei;Zhou Yi;Lai Yu(Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine,Nanning 530011,Guangxi Zhuang Autonomous Region,China;Guangxi University of Chinese Medicine,Nanning 530000,Guangxi Zhuang Autonomous Region,China)

机构地区：[1]广西中医药大学附属瑞康医院,广西壮族自治区南宁市530011 [2]广西中医药大学,广西壮族自治区南宁市530000

出　　处：《中国组织工程研究》2022年第11期1772-1779,共8页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金资助项目(81760796,81960803),项目参与人:章晓云;广西自然科学基金青年基金(2020GXNSFBA159053),项目负责人:章晓云;广西高校青年教师基础能力提升项目(2019KY0352),项目负责人:章晓云;广西研究生教育创新计划资助项目(YCBXJ2021019),项目负责人:夏天;广西研究生教育创新计划资助项目(YCSW2021219),项目参与人:夏天。

摘　　要：背景:骨质疏松症是一种严重影响中老年人健康的代谢性骨病,目前临床上治疗以西药为主。随着祖国传统医学的快速发展,近年来有大量研究发现淫羊藿中某些单体成分如淫羊藿素、淫羊藿苷、淫羊藿次苷、淫羊藿总黄酮、淫羊藿多糖等能够有效抑制骨吸收、骨破坏,促进成骨细胞增殖、分化,并最终起到防治骨质疏松的作用。目的:探讨淫羊藿主要活性单体成分介导相关信号通路防治骨质疏松症的作用机制,以期为今后骨质疏松症的防治提供新思路。方法:以"淫羊藿、骨质疏松症、骨细胞、单体成分、成骨分化、细胞增殖、信号通路"为中文检索词,以"Epimedium、Osteoporosis、Bonecell、Monomercomponent、Osteoblastdifferentiation、Cellproliferation、signalingpathway"为英文检索词,检索中国知网、PubMed、MEDLINE、万方、维普等数据库,筛选各数据库建库至2021年淫羊藿活性单体成分介导相关信号通路防治骨质疏松症的研究。结果与结论:(1)淫羊藿不良反应小,能加快成骨细胞增殖分化,还能直接抑制破骨细胞的骨吸收,在防治骨质疏松方面有着广阔的研究及应用前景;(2)淫羊藿总黄酮及其各活性单体成分发挥抗骨质疏松作用可能是通过内分泌激素、蛋白质、分子生物学以及基因学等多途径多层面来调控骨代谢实现的;(3)淫羊藿次苷Ⅱ相较于其他淫羊藿黄酮类化合物,其溶解性、渗透性较好,可能是淫羊藿黄酮中另一类具备抗骨质疏松作用的药效物质基础;(4)目前关于淫羊藿调控Wnt/β-catenin、MAPK、OPG/RANKL/RANK以及BMP/RunX2/OSX、Notch等信号通路主要靶点基因的研究很多,但是对于通路上的次要靶点基因以及各信号通路之间的协同作用仍有待进一步研究。BACKGROUND:Osteoporosis is a metabolic bone disease that seriously affects the health of middle-aged and elderly people.At present,western medicine is the main clinical treatment for osteoporosis.With the rapid development of traditional medicine in China,a large number of studies in recent years have found that some monomer components in Epimedium,such as icaritin,icariin,icariside,total flavonoids of Epimedium,and Epimedium polysaccharides,can effectively inhibit bone resorption and bone destruction,promote the proliferation and differentiation of osteoblasts,and ultimately prevent and treat osteoporosis.OBJECTIVE:To explore the mechanism by which the main active monomer components of Epimedium mediate related signaling pathways to prevent and treat osteoporosis,thereby providing new ideas for the prevention and treatment of osteoporosis in the future.METHODS:WanFang,CNKI,VIP,PubMed,and MEDLINE databases were retrieved with the keywords of"Epimedium,Osteoporosis,Bone cell,Monomer component,Osteoblast differentiation,Cell proliferation,signaling pathway"in Chinese and English,respectively.Relevant literatures published from their inceptions to 2021,which detailed the prevention and treatment of osteoporosis by active monomer components of Epimedium mediate related signaling pathways,were retrieved.RESULTS AND CONCLUSION:Epimedium has small adverse reactions,accelerates the proliferation and differentiation of osteoblasts,and directly inhibits the bone resorption of osteoclasts.Therefore,it has broad prospects in the prevention and treatment of osteoporosis.The total flavonoids of Epimedium and its active monomer components may play anti-osteoporosis effects through the regulation of bone metabolism via multi-channels and multiple levels such as endocrine hormones,protein,molecular biology,and genetics.Compared with other epimedium flavonoids,icariside II has better solubility and permeability.It may be another kind of Epimedium flavonoids with anti-osteoporosis effect.Currently,there are numerous studies about E

关 键 词：淫羊藿 骨质疏松症 骨细胞 单体成分 成骨分化 细胞增殖 信号通路 综述 

分 类 号：R459.9[医药卫生—治疗学] R318[医药卫生—临床医学]