Sinucrassins A-K, Casbane-type Diterpenoids from the South China Sea Soft Coral Sinularia crassa  

作　　者：Meng-Jun Wu Jiao Liu Jian-Rong Wang Juan Zhang Hong Wang Cheng-Shi Jiang Yue-Wei Guo 

机构地区：[1]Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals and College of Pharmaceutical Science,Zhejiang University of Technology,Hangzhou,Zhejiang 310014,China [2]State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,555 Zu Chong Zhi Road,Zhangjiang Hi-Tech Park,Shanghai 201203,China [3]School of Biological Science and Technology,University of Jinan,Jinan,Shandong 250022,China

出　　处：《Chinese Journal of Chemistry》2021年第9期2367-2376,共10页中国化学（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.81991521);the National Key Research and Development Program of China(No.2018YFC0310903);the SKLDR/SIMM Project(No.SIMM2103ZZ-06)。

摘　　要：A detailed chemical study on the Hainan soft coral Sinularia crass has resulted in the isolation and characterization of eleven cas-bane-type diterpenoids,named sinucrassins A-K(1-11),along with six known related ones(12-17).Their structures were elucidated by extensive spectroscopic analyses and comparison with the reported data.The absolute configurations of new compounds were determi ned by the X-ray diffracti on analysis and computer-assisted structural elucidati on in eluding 13C NMR data calculati on and time-dependent density functional theory/electronic circular dichroism calculation.

关 键 词：Sinularia crassa Casbane-type diterpenoid Configuration determination X-ray diffraction NMR spectroscopy 

分 类 号：O62[理学—有机化学]