Uncommon Polycyclic Merosesquiterpenoids and Asteriscanoids from the Hainan Soft Coral Sinularia hurnesi  

作　　者：Zi-Hui Chen Li-Gong Yao Qihao Wu Yue-Wei Guo 

机构地区：[1]Dedicated to Dr.Guido Cimino on the occasion of his 80th birthday.0 State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,555 Zu Chong Zhi Road,Zhangjiang Hi-Tech Park,Shanghai 201203,China [2]University of Chinese Academy of Sciences,No.19A Yuquan Road,Beijing 100049,China

出　　处：《Chinese Journal of Chemistry》2021年第9期2377-2385,共9页中国化学（英文版）

基　　金：supported by the National Key Research and Developme nt Program of China(No.2018YFC0310903);the Natural Science Foundation of China(No.81991521);the SKLDR/SIMM Projects(No.SIMM2103ZZ-06)。

摘　　要：A rare highly fused racemic merosesquiterpenoid,9-epi-verrubenzospirolactone(1),six new asteriscane-type sesquiterpenoids,sinuhumesins A-F(4-9),and two related known ones(10 and 11)were isolated from Hainan soft coral Sinularia humesi.Compound 1 was further separated by chiral HPLC resolution to one pair of enantiomers[(+)-1 and(-)-1],respectively.The full structures of the new compounds were unambiguously determined by extensive spectroscopic analysis,chemical computation approaches,modified Mosher's method and/or X-ray diffract!on analysis,as well as comparison with previously reported data of related model compounds.

关 键 词：Soft coral Sinularia humesi TERPENOIDS X-ray diffraction Configuration determination 

分 类 号：O62[理学—有机化学]