Isolation of Boswelliains A-E,Cembrane-Type Diterpenoids from Boswellia papyifera,and an Evaluation of Their Wound Healing Properties  

作　　者：Qi-Hua Yu Madhu Babu Sura Dai-Wei Wang Danling Huang Yong-Ming Yan Ya-Bin Jiao Qing Lu Yong-Xian Cheng 

机构地区：[1]Guangdong Pharmaceutical University,Guangzhou,Guangdong 510006,China [2]Institute for Inheritance-Based Innovation of Chinese Medicine,School of Pharmaceutical Sciences,Shenzhen University Health Science Center,Shenzhen,Guangdong 518060,China [3]Guangdong Key Laboratory for Functional Substances in Medicinal Edible Resources and Healthcare Products,School of Life Sciences and Food Engineering,Hanshan Normal University,Chaozhou,Guangdong 521041,China

出　　处：《Chinese Journal of Chemistry》2021年第9期2451-2459,共9页中国化学（英文版）

基　　金：supported financially by the National Key Research and Development Program of China(No.2017YFA0503900);the National Science Fund for Distinguished Young Scholars(No.81525026);the Shenzhen Fundamental Research Program(No.JCYJ20200109114003921);the Guangdong Key Laboratory for Functional Substances in Medicinal Edible Resources and Healthcare Products(No.2021B1212040015);the SZU Top Ranking Project(No.86000000210);the National Natural Science Foundation of China(No.81903508).

摘　　要：Boswelliai ns A-E(1-5),five new cembra ne-type diterpenoids,were isolated from the resin of Boswellia papyifera.Their structures,determined by using spectroscopic,computational and chemical methods,demonstrate that 2-5 are novel 4,5-seco-,4,5-seco-,9,10-seco-,and 6,7-seco-cembrane diterpenoids,and that 1,4 and 5 bear aldehyde moieties.An evaluation of the wound healing properties of these natural products along with a derivative of 2 shows that compounds 2 and 3 significantly stimulate proliferation,mobility and tuber formation of human umbilical vein endothelial cells(HUVECs)at the concentration of 20μmol/L.

关 键 词：Boswellia papyifera Natural products Structure elucidation seco-Cembrane diterpenoids Wound healing 

分 类 号：O62[理学—有机化学]