Three-Component Synthesis of 2-Heteroaryl-3-hydroxybenzo[b]- thiophenes under Transition-Metal-Free Conditions  

作　　者：Dahan Wang Fuhong Xiao Feng Zhang Guo-Jun Deng 

机构地区：[1]Key Laboratory for Green Organic Synthesis and Application of Hunan Province,Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of Education,College of Chemistry,Xiangtan University,Xiangtan,Hunan 411105,China [2]Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates,South China University of Technology,Guangzhou,Guangdong 510640,China

出　　处：《Chinese Journal of Chemistry》2021年第9期2483-2488,共6页中国化学（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.21871226,21502160,21572194);the Scientific Research Fund of Hunan Provincial Education Department(19B564);the Hunan Provincial Natural Science Foundation of China(No.2020JJ3032);the China Postdoctoral Science Foundation(Nos.2018M632976 and 2019T120709);the Scientific Research Fund of Xiangtan University(No.XDCX2020B110);the Open Fund of Guangdong Provincial Key Laboratory of Lumines-cence from Molecular Aggregates,Guangzhou,510640,China(South China University of Technology,No.2019B030301003).

摘　　要：A convenient synthetic route to 2-heteroaryl-3-hydroxybenzo[b]thiophene derivatives via K_(2)CO_(3)-promoted multicomponent cycliza-tion between o-halogenated benzaldehyde,2-methylquinolines and sulfur powder has been demonstrated.This reaction is performed smoothly under simple conditions to give the corresponding products in moderate to good yields.The resultant 3-hydroxybenzo[b]thiophenes have been proved to be versatile building blocks in a range of transition-metal-catalyzed cross-coupling reactions.

关 键 词：BENZOTHIOPHENES Transition-metal-free C-H activation Sulfur Multicomponent reactions 

分 类 号：O62[理学—有机化学]