Rh(Ⅲ)-Catalyzed Diverse C-H Functionalization of Iminopyridinium Ylides  

作　　者：Zhenzhen Dong Pengfei Li Xingwei Li Bingxian Liu 

机构地区：[1]NMPA Key Laboratory for Research and Evaluation of Innovative Drug,Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals,School of Chemistry and Chemical Engineering,Henan Normal University,Xinxiang,Henan 453007,China

出　　处：《Chinese Journal of Chemistry》2021年第9期2489-2494,共6页中国化学（英文版）

基　　金：The NSFC(Nos.21801066,2152520&U1804283 and 21801067);the Central Plains Scholars and Scientists Studio Fund(2018002);China Postdoctoral Science Foundation(2020M682307)are acknowledged.We also thank the financial support from Henan Key Laboratory of Organic Functional Molecules and Drug Innovation.

摘　　要：Divergent synthesis of useful skeletons has been realized via rhodium(Ⅲ)-catalyzed C-H activation of iminopyridinium ylides and coupling with various unsaturated coupling reagents.Isocoumarins and isoquinolones were obtained via cleavage of the C-N or N-N bond in the ylidic di recti ng group,while fluorinated alkenes were delivered with the di recti ng group in tact.The reactions occurred with wide substrate scopes and good efficiency under redox-neutral and air-tolerant conditions.Representative products exhibit solid-state fluoresce nt property and bioactivity of in hibiti on toward huma n cancer cells.

关 键 词：C-H functionalization Iminopyridinium ylide Diverse transformation Redox-neutral Ylidic directing group 

分 类 号：O62[理学—有机化学]