Characteristic Dihydroagarofuran Sesquiterpenoids with Neuroprotective Effects from the Celastraceae Plant Tripterygium wilfordii  

作　　者：Fangyou Chen Jing Wang Yongming Luo Chuangjun Li Jiwu Huang Jie Ma Dongming Zhang 

机构地区：[1]State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medico,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China [2]School of Pharmacy,Jiangxi University of Traditional Chinese Medicine,Nanchang,Jiangxi 330004,China [3]School of Pharmacy,China Pharmaceutical University,Nanjing,Jiangsu 211198,China

出　　处：《Chinese Journal of Chemistry》2021年第9期2547-2554,共8页中国化学（英文版）

基　　金：sponsored by the National Natural Science Foundation of China(Nos.21572275,81730093);the CAMS Inn ovation Fund for Medical Sciences(No.2017-I2M-3-010).

摘　　要：Ten new characteristic dihydroagarofuran sesquiterpenoids and three known ones were acquired from the Celastraceae plant Tripterygium wilfordii.Their structure characterizations were done through spectroscopic data,while compounds 10-12 were further con firmed by single crystal diffractions.Several dihydroagarofurans protected PC12 cells against H2O2-i nduced cytotoxicity as detected by CCK8 assay.Compounds 5-7 and 13 sign ificantly in creased the levels of reactive oxyge n species(ROS)and superoxide dismutase(SOD),and decreased malondialdehyde(MDA)levels.In addition,compounds 5-7 and 13 activated the Nrf2 signaling pathway and increased Nrf2,NQO1,and HO1 expression levels in PC12 cells after H_(2)O_(2) treatment.

关 键 词：Tripterygium wilfordii TERPENOIDS Structure elucidation Neuroprotective effects X-ray diffraction 

分 类 号：R285.5[医药卫生—中药学]