肿瘤相关性贫血原因  

The causes of cancer related anemia

作　　者：陈莹[1,2] 李银玲[1,2] 周祖平 蒲仕明[1,2,3] CHEN Ying;LI Yinling;ZHOU Zuping;PU Shiming(College of Life Sciences,Guangxi Normal University,Guilin 541006,China;Guangxi Universities Key Laboratory of Stem Cell and Biopharmaceutical Technology,Guangxi Normal University,Guilin 541004,China;Biomedical Research Center of Guangxi Normal University,Guilin 541004,China)

机构地区：[1]广西师范大学生命科学学院,桂林541006 [2]广西高校干细胞与医药生物技术重点实验室,广西师范大学,桂林541004 [3]广西师范大学生物医学研究中心,桂林541004

出　　处：《生命的化学》2021年第8期1747-1753,共7页Chemistry of Life

基　　金：国家自然科学基金项目(81972700,61827819);广西省自然科学基金项目(2018GXNSFBA281115)。

摘　　要：肿瘤相关性贫血(cancer related anemia,CRA)指肿瘤患者在其疾病的发展以及治疗过程中发生的贫血,是肿瘤患者常见的并发症。CRA对肿瘤患者的生存、疾病进展、生活质量均有一定的影响。出血、慢性炎症、骨髓抑制、缺铁、骨髓浸润等多种因素常引起CRA的发生,它们会通过红细胞生成减少或红细胞破坏增加的过程引发贫血。本文主要综述了CRA发展的主要病因和病因途径,以期为肿瘤相关性贫血的研究奠定一定的理论基础。Cancer related anemia(CRA)refers to anemia that occurs in cancer patients during the progression of the disease and treatment,and is a common complication in patients with cancer.CRA has an impact on the survival,disease progression and quality of oncology patients’life.Various factors such as bleeding,chronic inflammation,inhibition of bone marrow,iron deficiency,and bone marrow infiltration often cause the development of CRA,and they trigger anemia through a process of decreased erythropoiesis or increased erythrocyte destruction.This review focused on the principal etiologies and etiological pathways of CRA development,with a perspective of laying some theoretical foundation for research on cancer related anemia.

关 键 词：肿瘤 贫血 慢性炎症 缺铁 

分 类 号：R556[医药卫生—血液循环系统疾病] R730.6[医药卫生—内科学]