淋巴瘤患者外周血造血干细胞动员采集过程中相关因素对首次采集结果的影响  

Influence of related factors on the first results of peripheral blood hematopoietic stem cell mobilization in lymphoma patients

作　　者：郭秋霞 王吉刚 Guo Qiuxia;Wang Jigang(Department of Hematology,General Hospital of Northern Theater Command of PLA,Shenyang 110016,Liaoning Province,China)

机构地区：[1]解放军北部战区总医院血液科,辽宁省沈阳市110016

出　　处：《中国组织工程研究》2022年第1期7-11,共5页Chinese Journal of Tissue Engineering Research

摘　　要：背景:造血干细胞采集效果受多种因素综合影响,而明确的影响因素尚无定论,需要不断探索有可能影响造血干细胞采集的危险因素。目的:探讨50例淋巴瘤患者外周血造血干细胞动员采集过程中相关因素对首次采集结果的影响,并探讨采集结果与移植后造血重建的关系。方法:入选2015年1月至2020年1月接受自体外周血造血干细胞移植的50例淋巴瘤患者,分析患者的年龄、分期、骨髓侵犯、复发、放疗、粒细胞集落刺激因子持续使用时间、化疗疗程等因素对造血干细胞首次采集结果的影响,并探讨采集结果与中性粒细胞和血小板植入的关系。结果与结论:化疗疗程数与采集CD34^(+)细胞计数呈负相关;移植前复发的患者造血干细胞采集效果较差;放疗患者中动员失败的患者相对较多,失败率为88.9%,放疗对造血干细胞采集呈负面作用;输入CD34^(+)细胞计数越高,中性粒细胞植入越快,而对于移植后血小板植入的影响无显著差异,但是存在趋势;粒细胞集落刺激因子持续时间1-5 d和>5 d采集的CD34^(+)细胞数无明显差异。结果表明,对于淋巴瘤患者,过多的化疗、复发和放疗经历都会明显对造血干细胞造成损害,根据患者病情尽量待造血干细胞采集完毕后行放射治疗,以免对造血干细胞产生损伤。BACKGROUND:The effect of hematopoietic stem cell collection is affected by a variety of factors,but the clear influencing factors have not yet been determined.It is necessary to continuously explore the risk factors that may affect the collection of hematopoietic stem cells.OBJECTIVE:To investigate the influence of related factors on the first results of hematopoietic stem cell mobilization in peripheral blood of 50 patients with malignant lymphoma,and to explore the relationship between results and hematopoietic reconstruction after transplantation.METHODS:Totally 50 lymphoma patients undergoing autologous peripheral blood hematopoietic stem cell transplantation from January 2015 to January 2020 were included in this study so as to analyze the age,stage,bone marrow invasion,recurrence,radiotherapy,granulocyte colony-stimulating factor duration,chemotherapy duration and other factors on the first hematopoietic stem cell collection,and to explore the relationship of collection results with neutrophile granulocyte and platelet implantation.RESULTS AND CONCLUSION:The number of chemotherapy courses was negatively correlated with the collected CD34^(+)cell count.The results of hematopoietic stem cell collection were poor in patients with recurrence before transplantation,and among the radiotherapy patients,mobilization failure was relatively high,with a failure rate of 88.9%.Radiotherapy had a negative effect on hematopoietic stem cell collection.The higher the CD34^(+)cell count,the faster the neutrophile granulocyte implantation.However,the effect on post-transplantation platelet implantation was not so significant,but there was a trend.There was no difference in the number of CD34^(+)cells collected between granulocyte colony-stimulating factor duration of 1-5 days and granulocyte colonystimulating factor duration of over 5 days.The results concluded that in lymphoma patients,excessive chemotherapy,recurrence and radiotherapy experience will obviously cause damage to hematopoietic stem cells.Radiotherapy should be

关 键 词：淋巴瘤 CD34+细胞 自体造血干细胞 外周血 动员 采集 造血重建 

分 类 号：R457[医药卫生—治疗学] R318[医药卫生—临床医学]