间充质干细胞治疗卵巢早衰的最新进展及机制  

Latest progress and mechanisms of mesenchymal stem cells on premature ovarian failure

作　　者：李仲康 郑嘉华[1] 田彦鹏 黄向华[1] Li Zhongkang;Zheng Jiahua;Tian Yanpeng;Huang Xianghua(Second Hospital of Hebei Medical University,Shijiazhuang 050000,Hebei Province,China)

机构地区：[1]河北医科大学第二医院,河北省石家庄市050000

出　　处：《中国组织工程研究》2022年第1期141-147,共7页Chinese Journal of Tissue Engineering Research

摘　　要：背景:卵巢早衰是一种常见的妇科内分泌疾病,严重影响患者的生理、生育、心理健康,但目前针对卵巢早衰的治疗方法不能从根本上恢复患者的卵巢功能。间充质干细胞在各类疾病包括卵巢早衰的研究中展现出良好的治疗效果,已成为该领域的热点研究方向,且各项研究已经深入到探究其内在治疗机制。目的:总结并分析近年来关于间充质干细胞治疗卵巢早衰的研究进展,深入探究其存在的相关治疗机制,进而评估其应用于临床治疗的潜力,为间充质干细胞治疗卵巢早衰的进一步研究及临床应用提供理论依据。方法:以"间充质干细胞,卵巢早衰"及"mesenchymal stem cells,premature ovarian failure or premature ovarian insufficiency"分别作为中、英文关键词,在中国知网数据库及PubMed数据库对近年的相关文献进行检索,最终纳入符合要求的55篇文献进行综述。结果与结论:各类间充质干细胞对卵巢早衰的细胞、动物模型都有很好的治疗效果,具体机制包括间充质干细胞归巢作用、促进细胞增殖、抑制细胞凋亡、分化、免疫调节、分泌多种细胞因子、调节细胞自噬和调节卵巢微环境等。除大量的基础研究,相关临床研究也已有序展开,但仍处于起步阶段,其安全性和有效性仍需要进一步加以验证。BACKGROUND:Premature ovarian failure is a common gynecological endocrine disease,which seriously affects the patient’s physiological,fertility,and psychological functions.Unfortunately,curative therapies are not available at present,and current treatments are mainly address the symptoms.Mesenchymal stem cell transplantation is performed with excellent results and has been widely studied in premature ovarian failure.However,the mechanisms behind it are still undergoing intensive research.OBJECTIVE:To summarize and analyze the research progress of mesenchymal stem cells in the treatment of premature ovarian failure in recent years,to explore the related treatment mechanisms,and to evaluate its potential for clinical treatment so as to provide a theoretical basis for research and clinical application.METHODS:We searched the articles in CNKI and PubMed with the keywords of"mesenchymal stem cells,premature ovarian failure,premature ovarian insufficiency"in Chinese and English,respectively.Finally,55 articles met the criteria for review.RESULTS AND CONCLUSION:All kinds of mesenchymal stem cells have a great therapeutic effect on premature ovarian failure cell and animal models.The therapeutic mechanisms include homing,promoting cell proliferation,inhibiting cell apoptosis,differentiation,immunoregulation,secreting a variety of cytokines,regulating autophagy and regulating ovarian microenvironment.In addition to a large number of basic researches,related clinical researches have also been carried out.However,its clinical application research is still in its infancy,and its safety and effectiveness still need to be verified by further clinical studies.

关 键 词：卵巢早衰 间充质干细胞 外泌体 微囊泡 颗粒细胞 卵泡 治疗机制 细胞增殖 细胞凋亡 综述 

分 类 号：R459.9[医药卫生—治疗学] R318[医药卫生—临床医学]