组织工程皮肤的研究热点及应用价值  

Research hotspots and application value of tissue-engineered skin

作　　者：林苗远 李豫皖 刘毅 陈贝 张莉 Lin Miaoyuan;Li Yuwan;Liu Yi;Chen Bei;Zhang Li(Affiliated Hospital of Zunyi Medical University,Zunyi 563000,Guizhou Province,China;Department of Sports Medicine,Peking University Third Hospital,Institute of Sports Medicine of Peking University,Beijing Key Laboratory of Sports Injuries,Beijing 100191,China;Department of Joint Surgery,Affiliated Hospital of Zunyi Medical University,Zunyi 563000,Guizhou Province,China)

机构地区：[1]遵义医科大学附属医院,贵州省遵义市563000 [2]北京大学第三医院运动医学科,北京大学运动医学研究所,运动医学关节伤病北京市重点实验室,北京市100191 [3]遵义医科大学附属医院关节外科,贵州省遵义市563000

出　　处：《中国组织工程研究》2022年第1期153-159,共7页Chinese Journal of Tissue Engineering Research

基　　金：中国博士后科学基金面上项目(2020M680258),项目负责人:李豫皖。

摘　　要：背景:组织工程皮肤在促进皮肤组织创面修复、无瘢痕愈合方面具有较好的运用前景。目的:综述目前组织工程皮肤在体内外的研究进展、应用及价值。方法:应用计算机检索CNKI数据库及PubMed数据库中收录的相关文献,中文检索词为"间充质干细胞,生长因子,皮肤,创面,皮肤修复,创面愈合,再生医学,组织工程,支架材料",英文检索词为"mesenchymal stem cells,growth factor,skin,wound,skin repair,wound healing,regenerative medicine,tissue engineering,scaffolds"。查阅国内外近年来关于组织工程皮肤治疗皮肤组织损伤的相关文献,也包括对间充质干细胞、生长因子、支架材料和敷料等新治疗手段的研究进展进行总结。排除与文章主题不相关的文献,最终纳入78篇文献进行结果分析。结果与结论:组织工程皮肤构建涉及到种子细胞的筛选、生长因子的应用以及支架材料多个环节要素的组合。间充质干细胞是组织工程皮肤种子细胞的重要来源之一,生长因子优化组织培养环境,支架材料提供适当的机械支持。因此,如何选择适当的种子细胞、生长因子和支架材料构建组织工程化皮肤治疗创面损伤,加快修复,是未来应探究的重点和研究方向,此外创面敷料材料的开发也是一个新的领域。BACKGROUND:Tissue-engineered skin has a good application prospect in promoting skin tissue wound repair and scarless healing.OBJECTIVE:To review the current research progress,application and value of tissue-engineered skin in vivo and in vitro.METHODS:A computer was used to search the relevant articles in the CNKI database and PubMed database.The Chinese and English search terms were"mesenchymal stem cells;growth factors;skin;wounds;skin repair;wound healing;regenerative medicine;tissue engineering;scaffolds".The domestic and foreign related application articles on tissue-engineered skin construction in the treatment of skin tissue injury in recent years were checked,and the research progress of mesenchymal stem cells,growth factors,scaffold materials and dressings for new treatment methods for tissue repair was also summarized.The articles irrelevant to the subject of this article were excluded,and 78 articles were finally included for the result analysis.RESULTS AND CONCLUSION:The construction of tissue-engineered skin involves the selection of seed cells,the application of growth factors,and the combination of multiple elements of scaffold materials.Mesenchymal stem cells are one of the important sources of tissue-engineered skin seed cells.Growth factors optimize the tissue culture environment,and scaffold materials provide appropriate mechanical support.Therefore,how to select appropriate seed cells,growth factors and scaffold materials to construct tissue-engineered skin to treat wounds and speed up repair is the focus and research direction that should be explored in the future.In addition,the development of wound materials is also a new field.

关 键 词：间充质干细胞 生长因子 皮肤 创面 再生医学 组织工程 支架材料 综述 

分 类 号：R459.9[医药卫生—治疗学] R318.19[医药卫生—临床医学]