GLP-1受体激动剂促创面愈合及其分子机制  

Molecular mechanisms of glucagon-like peptide 1 receptor agonists promote wound healing

作　　者：李炫净 金莉莉[1] 王秋雨[1] 张殿宝[2] LI Xuanjing;JIN Lili;WANG Qiuyu;ZHANG Dianbao(Life Science School,Liaoning University,Shenyang 110036,China;College of Basic Medical Science,China Medical University,Shenyang 110122,China)

机构地区：[1]辽宁大学生命科学院,沈阳110036 [2]中国医科大学基础医学院,沈阳110122

出　　处：《生命的化学》2021年第9期1989-1994,共6页Chemistry of Life

基　　金：国家自然科学基金项目(31071916,81703102,82073419)。

摘　　要：皮肤作为人体最大的器官覆盖全身,具有重要的屏障保护作用。皮肤屏障一旦遭到破坏就会形成创面。2型糖尿病、肥胖等多种疾病因素影响着创面愈合的速度,造成慢性难愈创面。胰高血糖素样肽1受体激动剂通过调控炎症反应、促角质形成细胞迁移、促血管及肉芽组织生成和影响代谢调节等环节,起到促进创面愈合的作用。本文结合本课题组的相关研究工作,综述了胰高血糖素样肽1受体激动剂促进创面愈合的分子机制,供从事相关研究工作的人员参考。As the largest organ of the human body, the skin plays a key role in barrier protection covering the whole body. Once skin barrier is destroyed, wounds will be achieved. Various disease factors including type 2 diabetes mellitus and obesity can affect the speed of wound healing, leading to refractory wounds.Glucagon-like peptide 1(GLP-1) receptor agonists promoted wound healing by regulating inflammatory response, promoting keratinocyte migration, promoting angiogenesis and granulation tissue formation, and affecting metabolism regulation. Combined with the relevant research work of our group, this review provided an overview about molecular mechanisms of GLP-1 receptor agonists in promoting wound healing, which provided a reference for people engaging in related research work.

关 键 词：胰高血糖素样肽1受体激动剂 创面愈合 抗炎 角质形成细胞 血管生成 代谢调控 

分 类 号：R641[医药卫生—外科学]