郑州市常见风湿免疫病病例特征及T淋巴细胞亚群和调节性T细胞变化研究  

Characteristics of common rheumatic immune diseases and the changes of T lymphocyte subsets and Treg cells in Zhengzhou

作　　者：赵常华 姬永辉 丁艳霞[1] ZHAO Chang-hua;JI Yong-hui;DING Yan-xia(The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学第一附属医院,河南郑州450052

出　　处：《华南预防医学》2021年第10期1272-1275,共4页South China Journal of Preventive Medicine

摘　　要：目的分析常见风湿免疫病类风湿性关节炎(RA)、强直性脊柱炎(AS)、骨关节炎(OA)病例特征及T淋巴细胞亚群和调节性T(Treg)细胞变化。方法以2017年1月1日至2019年12月31日郑州市某医院免疫风湿门诊就诊的成年RA、AS、OA病例作为研究对象(病例组),并设立健康对照组,检测2组的T淋巴细胞和Treg细胞水平进行比较分析,并对病例组病例特征进行描述性分析。结果共纳入成年RA、AS、OA病例1 486例,男女性别比为0.56∶1,年龄18~67岁,18~44岁占35.5%。RA、AS、OA病例分别有327、270、889例,RA、AS、OA 3种常见风湿免疫性疾病病例的性别、年龄、家族史的分布差异均有统计学意义(P<0.05或P<0.01)。T淋巴细胞亚群和Treg细胞在RA、AS、OA病例、健康人群中的差异均有统计学意义(均P<0.01),RA、AS、OA病例的CD4、CD4/CD8水平均较健康人群水平高,CD8水平较健康人群低。AS、OA病例CD4^(+)T、CD25^(+)T、CD4^(+)CD25^(+)T、CD4^(+)CD25^(+)CD127-T水平均较健康人群高。结论 RA、AS、OA病例具有一定的性别、年龄分布特征,不同风湿免疫性疾病病例间T淋巴细胞亚群和Treg细胞不同,均有不同程度的免疫功能紊乱,应当引起重视。Objective To analyze the characteristics of common rheumatic immune diseases such as rheumatoid arthritis(RA),ankylosing spondylitis(AS),osteoarthritis(OA)and the changes of T lymphocyte subsets and Treg cells.Methods The adult cases of RA,AS and OA in the clinic of immunology and rheumatology of a hospital in Zhengzhou from January 1,2017 to December 31,2019 were taken as the research object(case group),and a healthy control group was established. The levels of T lymphocytes and Treg cells in the two groups were detected for comparative analysis,and the case characteristics of the case group were descriptive analyzed.Results A total of 1 486 adult cases of RA,AS and OA were included,with a male-female ratio of 0.56∶1,aged 18-67 years,18-44 years old accounted for 35.5%. There were 327,270,and 889 cases of RA,AS,and OA,respectively. The differences in the gender,age,and family history of the three common rheumatic immune disease cases of RA,AS,and OA were statistically significant(P<0.05 or P<0.01). The differences between T lymphocyte subsets and Treg cells in RA,AS,OA cases and healthy people were statistically significant(all P<0.01). The CD4 and CD4/CD8 levels of RA,AS,and OA cases were all higher than those of healthy people,and the CD8 level was lower than that of healthy people. The CD4^(+)T,CD25^(+)T,CD4^(+)CD25^(+)T,and CD4^(+)CD25^(+)CD127-T levels of AS and OA cases were both higher than those of healthy people.Conclusion RA,AS and OA cases have certain characteristics of gender and age composition ratio. Different cases of rheumatic immune diseases have different levels of T lymphocyte subsets and Treg cells,and have varying degrees of immune dysfunction,which should be paid attention to.

关 键 词：类风湿性关节炎 强直性脊柱炎 骨关节炎 免疫学 

分 类 号：R181.3[医药卫生—流行病学]