宜昌市成人带状疱疹发病与其生命早期饥荒暴露相关研究  

Study on the incidence of adult herpes zoster in Yichang city and its association with early-life famine exposure

作　　者：丁雄 蒋蔚[2] 胡跃华[3,4] 蒋静 武英[1] 徐承中 吴周志[2] 余云芳[2] 刘晓俊[2] 李贵文[2] 殷大鹏[3] Ding Xiong;Jiang Wei;Hu Yuehua;Jiang Jing;Wu Ying;Xu Chengzhong;Wu Zhouzhi;Yu Yunfang;Liu Xiaojun;Li Guiwen;Yin Dapeng(School of Public Health,North China University of Science and Technology,Tangshan 063210,China;Yichang Center for Disease Control and Prevention,Yichang 443003,China;Chinese Center for Disease Control and Prevention,Beijing 102206,China;Beijing Advanced Innovation Center for Big Data-Based Precision Medicine,Beihang University&Capital Medical University,Beijing 100083,China)

机构地区：[1]华北理工大学公共卫生学院,唐山063210 [2]宜昌市疾病预防控制中心,443003 [3]中国疾病预防控制中心,北京102206 [4]北京航空航天大学&首都医科大学,北京大数据精准医疗高精尖创新中心,100083

出　　处：《中华预防医学杂志》2021年第11期1328-1331,共4页Chinese Journal of Preventive Medicine

基　　金：北京市自然科学基金-海淀原始创新联合基金(L202008);北航-首医大数据精准医疗高精尖创新中心计划(BHME-201801);中国疾病预防控制中心科研项目-带状疱疹发病影响因素的研究(59911917)。

摘　　要：基于宜昌健康大数据平台,纳入2018年9月至2019年9月期间的850608例就诊患者为研究对象,根据出生日期将研究对象分为儿童早期饥荒暴露组、胎儿期饥荒暴露组和非饥荒暴露组,分析宜昌市成人带状疱疹(HZ)发病情况并分析生命早期饥荒暴露与成年HZ的相关性。2019年宜昌市城区成年HZ粗发病率6.83‰,女性(7.26‰)高于男性(6.40‰)。与非饥荒暴露组相比,胎儿期饥荒暴露与成年HZ发病相关(OR=1.21;95%CI:1.01~1.45,P=0.041)。按性别分层后,仅在女性中发现胎儿期饥荒暴露与成年HZ发病相关(OR=1.28;95%CI:1.02~1.61,P=0.034)。Based on Yichang health big data platform,850608 patients from September 2018 to September 2019 were included in this study.According to the date of birth,the participants were divided into early childhood famine exposure group,fetal famine exposure group and non-famine exposure group.The incidence of adult herpes zoster(HZ)in Yichang city was analyzed,and the correlation between early life famine exposure and adult HZ was analyzed.In 2019,the crude incidence rate of adult HZ in Yichang was 6.83‰.The crude incidence rate of adult HZ in females(7.26‰)was higher than that in males(6.40‰).Compared with the non-famine exposure group,fetal famine exposure was associated with the incidence of adult HZ(OR=1.21;95%CI:1.01-1.45,P=0.041).After stratification by sex,fetal famine exposure was only found to be associated with the onset of adult HZ in females(OR=1.28,95%CI:1.02-1.61,P=0.034).

关 键 词：带状疱疹 饥荒暴露 发病率 大数据 

分 类 号：R752.12[医药卫生—皮肤病学与性病学]