流感病毒抗原性进化及对流感疫苗研发的启示  

Antigenic evolution of influenza virus and the implications for influenza vaccine development

作　　者：安艺萌 周旭 王佑春 黄维金 An Yimeng;Zhou Xu;Wang Youchun;Huang Weijin(Shanghai Institute of Biological Products Co.,LTD,Shanghai 200051,China;AIDS Department,Institute of Biological Products,China Food and Drug Testing Institute,Beijing 102629,China)

机构地区：[1]上海生物制品研究所有限责任公司,200051 [2]中国食品药品检定研究院生物制品检定所艾滋室,国家卫生健康委员会生物技术产品检定方法与标准化重点实验室,国家药品监督管理局生物制品质量研究与评价重点实验室,北京102629

出　　处：《中华预防医学杂志》2021年第11期1339-1345,共7页Chinese Journal of Preventive Medicine

基　　金：国家科技重大专项(2018ZX09101001)。

摘　　要：流感病毒持续而广泛地影响全球人类健康,其广泛的动物宿主特性、高度变异的特点导致抗原不断漂移,易感人群更迭,引起全球流感流行反复发生,也影响着季节性流感疫苗的保护效果。本研究以多种亚型的甲型流感病毒为例,从抗原性漂移对抗原性的影响、季节性流感疫苗株与流行株的匹配度、广谱流感疫苗研发的思路等方面,对相关的研究进展作一综述,以加深对流感病毒抗原性进化的理解,为流感疫苗未来研发思路提供参考。Influenza virus has a continuous and extensive impact on human health around the world.Its extensive animal host characteristics and highly variable characteristics lead to continuous antigen drift and change of susceptible populations,causing repeated global influenza epidemics,and also affecting the protective effect of seasonal influenza vaccine.This research in a number of subtypes of influenza a virus,for example,from the antigenic drift of antigenicity,influence of the seasonal influenza vaccine strains and popular strain compatibility,broad-spectrum flu vaccine development train of thought,etc.summarizes the progress of relevant research,to deepen the understanding of the influenza virus antigenic evolution,provide reference for flu vaccine development in the future.

关 键 词：流感 人 病毒 抗原变异 疫苗 

分 类 号：R392-33[医药卫生—免疫学]