人类免疫缺陷病毒和梅毒螺旋体双重感染眼部表现及治疗的研究进展  

Research progress of ocular manifestations and treatments of human immunodeficiency virus and syphilis co-infection

作　　者：周慧颖[1,2] 叶俊杰 Zhou Huiying;Ye Junjie(Department of Ophthalmology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China;Department of Ophthalmology,Beijing Tian tan Hospital,Capital Medical University,Beijing 100070,China)

机构地区：[1]中国医学科学院北京协和医学院,北京协和医院眼科,100730 [2]首都医科大学附属北京天坛医院眼科,100070

出　　处：《中华眼科杂志》2021年第11期865-870,共6页Chinese Journal of Ophthalmology

摘　　要：获得性免疫缺陷综合征(AIDS)是累及全身多系统的致死性疾病, 由人类免疫缺陷病毒(HIV)感染引起。梅毒是由梅毒螺旋体感染引起的累及全身多系统的慢性传染性疾病。近年我国梅毒和AIDS的发病率均呈上升趋势, 二者有相同的高危人群和相似的传播途径, 双重感染患者日渐增多, 且二者相互影响。部分双重感染患者以眼部症状首发就诊于眼科, 其眼部表现多样化, 缺乏典型、特异性症状和体征, 易漏诊、误诊, 治疗的失败率和复发率高。本文汇总国内外近年相关研究进展, 总结双重感染的流行病学特征、眼部表现、检测诊断及治疗, 以期为临床诊疗和研究工作提供参考。Acquired immune deficiency syndrome caused by human immunodeficiency virus(HIV)infection is a fatal disease involving multiple systems.Syphilis is a systemic chronic infection disease caused by treponema pallidum infection.In recent years,the incidence of the two infectious diseases in China has been on the rise.Both of them have the same high-risk population and similar transmission routes,and co-infection is increasing day by day.They can influence each other.Syphilis significantly increases the risk of HIV infection,and HIV is able to change the natural course of syphilis.HIV and syphilis co-infection leads to diverse ocular manifestations which are not typical or specific.This condition results in not only a high rate of missed diagnosis and misdiagnosis,but also a high rate of treatment failure and recurrence.There is a high correlation between ocular syphilis and neurosyphilis in HIV-positive patients.Many patients with HIV/syphilis co-infection visit eye clinics for the initial symptom.In order to provide reference for clinical diagnosis,treatment and research,this article reviews the recent advances on the studies of the co-infection of HIV and syphilis,including epidemiological characteristics,ocular manifestations and treatments.

关 键 词：同时感染 HIV感染 梅毒 眼表现 治疗 

分 类 号：R759.1[医药卫生—皮肤病学与性病学] R77[医药卫生—临床医学] R512.91