Synthesis of 2-aminothiazoles via rhodium-catalyzed carbenoid insertion/annulation of sulfoxonium ylides with thioureas  

作　　者：Yuncan Chen Shan Lv Ruizhi Lai Yingying Xu Xin Huang Jianglian Li Guanghui Lv Yong Wu 

机构地区：[1]Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province,Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology,West China School of Pharmacy,Sichuan University,Chengdu 610041,China [2]Department of Pharmacy,Taihe Hospital,Hubei University of Medicine,Shiyan 442000,China

出　　处：《Chinese Chemical Letters》2021年第8期2555-2558,共4页中国化学快报（英文版）

基　　金：support from the National Natural Science Foundation of China (Nos.81373259 and 81573286);Sichuan Science and Technology Program (Nos.2020YJ0221 and 2018JY0537)。

摘　　要：Sulfoxonium ylides as carbene precursors couple smoothly with thioureas in the presence of 5 mol% of rhodium(Ⅱ) acetate dimmer via carbenoid insertion to afford the corresponding 2-aminothiazoles with high chemoselectivity,providing a facile and efficient approach to access a variety of 2-aminothiazole derivatives with good functional groups tolerance.

关 键 词：2-Aminothiazoles Carbene Rhodium Sulfoxonium ylides ANNULATION 

分 类 号：O626.25[理学—有机化学]