Rhodium(Ⅲ)-catalyzed [4+2] annulation of N-arylbenzamidines with1,4,2-dioxazol-5-ones: Easy access to 4-aminoquinazolines via highly selective C-H bond activation  

作　　者：Jie Ren Yanzhen Huang Chao Pi Xiuling Cui Yangjie Wu 

机构地区：[1]Henan Key Laboratory of Chemical Biology and Organic Chemistry,Key Laboratory of Applied Chemistry of Henan Universities,Green Catalysis Center and College of Chemistry,Zhengzhou University,Zhengzhou 450052,China

出　　处：《Chinese Chemical Letters》2021年第8期2592-2596,共5页中国化学快报（英文版）

基　　金：financial support from the Ministry of Science and Technology of China (No.2016YFE0132600);Henan Center for Outstanding Overseas Scientists (No.GZS2020001);Zhengzhou University。

摘　　要：A novel approach for the synthesis of 4-aminoquinazolines has been developed via rhodium(Ⅲ)-catalyzed [4+2] annulation of N-arylbenzamidines with 1,4,2-dioxazol-5-ones.This reaction features excellent regioselectivity,broad substrate scope and high step economy,which would provide the refe rence for the construction of the fused 4-aminoquinazolines with biologically and pharmacologically active compounds.

关 键 词：[4+2]Annulation N-Arylbenzamidine 4-Aminoquinazoline Excellent regioselectivity High step economy 

分 类 号：O626[理学—有机化学]