微透析与微流控技术联合应用于体液监测的研究进展  

Advances in microdialysis-coupled microfluidics for body fluid monitoring

作　　者：周星贝 丁涛 王树水 Zhou Xingbei;Ding Tao;Wang Shushui(School of Medicine,South China University of Technology,Guangzhou 510006,China;Department of Pediatric Cardiology,Guangdong Provincial People′s Hospital,Guangdong Academy of Medical Sciences,Guangdong Cardiovascular Institute,Guangzhou 510080,China)

机构地区：[1]华南理工大学医学院,广州510006 [2]广东省人民医院,广东省医学科学院,广东省心血管病研究所心儿科,广州510080

出　　处：《中华检验医学杂志》2021年第10期970-977,共8页Chinese Journal of Laboratory Medicine

摘　　要：微透析是一种新型的采样技术,可快速、连续地对目标位置进行取样,近年来广泛应用于体液采集,特别是针对难以直接获取样品部位,如颅内、组织间隙等。微流控技术为体液检测提供了新的分析平台,同时还具有微量、高通量、自动化的特点,为快速、低成本的临床生化分析提供了一条可行的技术途径。在临床实践中,很多情况下要求体液分析能快速地回报结果和/或能长期动态监测某项指标的变化情况,但现有的技术手段不足以实现这个需求。微透析与微流控技术的联合应用为解决这一问题提供了新的视角。Microdialysis is a novel technique for rapid and continuous sampling of body fluid in the extracellular space,especially for some hard-to-obtain samples,e.g.cerebrospinal fluid,interstitial fluid.Microfluidic technology plays a significant role in body fluid analysis because of its miniaturization,high-throughput,and automation,offering a feasible method for rapid and low-cost biochemical analysis.In clinical practice,body fluid analysis is often required to be fast and/or capable of long-termly monitoring certain biomarkers.However,current technologies are insufficient to meet this requirement.The combination of microdialysis and microfluidic technologies could provide a new perspective to solve this problem.

关 键 词：微透析 微流控 生化监测 体液活检 血液检测 神经递质 

分 类 号：R446[医药卫生—诊断学]