脑梗死患者体内颈动脉斑块情况与凝血指标表达  

Carotid artery plaque and expression of coagulation index in patients with cerebral infarction

作　　者：丁洁颖[1] 孙洪[1] 陈倩倩[2] 邢彤 Ding Jieying;Sun Hong;Chen Qianqian;Xing Tong(Department of Clinical Laboratory,Shanghai Ninth People's Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200011,China;Department of Ultrasound Diagnostic,Shanghai Ninth People's Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200011,China;Department of Vascular Surgery,Berjing Chaoyang Emergency Medical Center,Beijing 100122,China)

机构地区：[1]上海交通大学医学院附属第九人民医院检验科,上海200011 [2]上海交通大学医学院附属第九人民医院超声诊断科,上海200011 [3]北京朝阳急诊抢救中心血管外科,北京100122

出　　处：《血管与腔内血管外科杂志》2021年第5期576-579,共4页Journal of Vascular and Endovascular Surgery

基　　金：上海交通大学医工交叉基金(YG2016QN15)。

摘　　要：目的探讨脑梗死患者体内颈动脉斑块情况与凝血指标表达。方法收集2019年1月至2021年1月上海交通大学医学院附属第九人民医院收治的102例脑梗死患者为观察组,同期选取健康体检者102例为对照组。比较两组斑块检出率和不同颈动脉狭窄程度,颈动脉颈动脉内中膜厚度(IMT)和凝血指标表达水平;比较不同颈动脉狭窄程度观察组患者的血浆纤维蛋白原(Fib)和D-二聚体(D-D)水平。结果两组斑块检出率和狭窄程度比较,差异有统计学意义(P<0.05)。观察组患者颈动脉IMT厚于对照组受试者,凝血指标Fib和D-D表达水平高于对照组受试者,差异有统计学意义(P<0.01)。重度狭窄的观察组患者Fib和D-D表达水平高于对照组受试者,差异有统计学意义(P<0.05)。结论脑梗死患者体内凝血指标Fib和D-D表达水平升高,且重度狭窄程度的脑梗死患者Fib和D-D表达水平最高,这为临床对脑梗死的二级预防提供了一定新的思路。Objective To investigate the condition of carotid artery plaque and the expression of coagulation index in patients with cerebral infarction.Method Clinical data of 102 patients with cerebral infarction admitted to the Shanghai Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine from January 2019 to January 2021 was collected as the observation group,and 102 healthy patients were selected as the control group during the same period;The detection rate of plaque,different degrees of carotid artery stenosis,intima-media thickness(IMT)and expression of coagulation indexes were compared between the two groups.The levels of fibrinogen(Fib)and D-dimer(D-D)in patients with different degrees of carotid stenosis were compared.Result There were statistically significant differences in plaque detection rate and stenosis degree between the two groups(P<0.05).The thickness of carotid IMT in the observation group was higher than that in the control group,and the expression levels of coagulation indexes Fib and D-D in the observation group were higher than those in the control group(P<0.01).The expression levels of Fib and D-D were the highest in the observation group with severe stenosis(P<0.05).Conclusion The expression levels of coagulation indexes Fib and D-D in patients with cerebral infarction are increased,and the expression levels of Fib and D-D are highest in patients with severe stenosis of cerebral infarction,which provided some new ideas for secondary prevention of cerebral infarction in clinical practice.

关 键 词：脑梗死 颈动脉斑块 内中膜厚度 D-二聚体 

分 类 号：R543[医药卫生—心血管疾病]