超声引导下聚桂醇硬化剂注射治疗大隐静脉曲张的疗效观察  

Efficacy of lauromacrogol sclerosing agent injection under ultrasound in the treatment of great saphenous varicose vein

作　　者：赵磊[1] 杨铮[1] 周辰光[1] Zhao Lei;Yang Zheng;Zhou Chenguang(Department of Vascular Surgery,the No.2 Hospital of Baoding,Baoding 071051,Hebei,China)

机构地区：[1]保定市第二医院血管外科,河北保定071051

出　　处：《血管与腔内血管外科杂志》2021年第5期595-599,共5页Journal of Vascular and Endovascular Surgery

摘　　要：目的探讨超声引导下聚桂醇硬化剂注射治疗大隐静脉曲张的临床疗效。方法收集2019年5月至2021年2月在保定市第二医院接受治疗的大隐静脉曲张患者的临床资料,根据治疗方式的不同将其分为手术组(采用大隐静脉高位结扎剥脱术治疗)和硬化组(采用超声下聚桂醇硬化剂注射治疗),每组65例。比较两组患者的术后下肢静脉曲张临床表现-病因学-解剖学-病理生理学(CEAP)分级、手术及术后恢复情况。比较两组患者术前1 d、术后1 d的血清炎性反应指标[肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)]和血管内皮功能指标[外周血循环内皮细胞(CEC)计数、内皮素-1(ET-1)及一氧化氮(NO)]。比较两组患者出院前的术后并发症发生情况。结果术后,硬化组患者的CEAP分级明显低于手术组患者,差异有统计学意义(P<0.01)。硬化组患者的手术时间、术后首次下床活动时间、住院时间均明显短于手术组患者,术中出血量明显少于手术组患者,差异均有统计学意义(P<0.01)。术后1 d,硬化组患者的TNF-α、IL-6、CEC、ET-1水平均明显低于手术组患者,NO水平明显高于手术组,差异均有统计学意义(P<0.01)。硬化组患者的术后并发症总发生率为6.15%(4/65),低于手术组患者的20.00%(13/65),差异有统计学意义(P<0.05)。结论超声下聚桂醇硬化剂注射治疗大隐静脉曲张的临床疗效良好,能够减轻术后炎性反应,改善血管内皮功能,安全性较高。Objective To study the efficacy of ultrasound-guided injection of lauromegol sclerosing agent in the treatment of great saphenous varicose vein.Method The clinical data of patients with great saphenous varicose veins from May 2019 to February 2021 in the No.2 Hospital of Baoding were selected.According to different treatment methods,they were divided into surgery group(high ligation and stripping of great saphenous vein)and sclerosis group(injection of lauromegolsclerosing agent under ultrasound),with 65 cases in each group.The clinical-etiology-anatomy-pathophysiology(CEAP)grade,surgery and postoperative recovery of the two groups were compared.Serum inflammatory response indexes including tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)were observed 1 day before and 1 day after surgery,and vascular endothelial function indexes including peripheral blood circulating endothelial cell(CEC)count,endothelin-1(ET-1)and nitric oxide(NO)levels were observed in the two groups.Before discharge,the incidence of postoperative complications in the two groups was statistically analyzed.Result The CEAP grade in the sclerosis group was lower than that in the surgery group,the difference was statistically significant(P<0.01).The surgery time,the first postoperative activity time out of bed and the length of hospital stay in the sclerosis group were shorter than those in the surgery group,and the intraoperative blood loss was less than that in the surgery group,with statistical significance(P<0.01).On the first day after surgery,the levels of TNF-α,IL-6,CEC and ET-1 in the sclerosis group were lower than those in surgery group,and the level of NO was higher than that in surgery group,the difference were statistically significant(P<0.01).The total incidence rate of postoperative complications in the sclerosis group was 6.15%(4/65),which was lower than 20.00%(13/65)in the surgery group,and the difference was statistically significant(P<0.05).Conclusion The treatment of great saphenous varicose vein with sclerosclerosis inj

关 键 词：大隐静脉曲张 超声 聚桂醇硬化剂 剥脱术 腔内注射治疗 

分 类 号：R543[医药卫生—心血管疾病]