溃疡性结肠炎合并贫血的临床因素分析  

Analysis of Clinical Factors of Ulcerative Colitis Complicated With Anemia

作　　者：陈文轩 李宝悦 卜祥点 马娜[1] 张哲 冯百岁[1] CHEN Wenxuan;LI Baoyue;BU Xiangdian;MA Na;ZHANG Zhe;FENG Baisui(Department of Gastroenterology, the Second Affiliated Hospital of Zhengzhou University, Zhengzhou 450014)

机构地区：[1]郑州大学第二附属医院消化内科,450014

出　　处：《胃肠病学》2021年第3期155-159,共5页Chinese Journal of Gastroenterology

基　　金：河南省科技发展计划项目(212102310803);河南省医学科技攻关(联合共建)项目(2018020164);郑州大学学科建设重点专项前沿交叉专项(XKZDQY201906);2021年度郑州市科技惠民计划项目(2021KJHM0018)。

摘　　要：背景:炎症性肠病的患病率在世界范围内不断上升,贫血作为其最常见的肠外表现之一,常未得到充分诊断且治疗不足。目的:分析溃疡性结肠炎(UC)患者的临床因素与贫血的关系。方法:回顾性纳入2019年9月—2020年5月在郑州大学第二附属医院住院治疗的确诊UC患者60例,同期60名健康体检者作为对照组。采集UC患者入院时空腹静脉血检查数据,分析贫血指标及其与临床因素的相关性。结果:UC患者红细胞(RBC)计数、血红蛋白(Hb)、血细胞比容(HCT)、平均红细胞体积(MCV)、平均红细胞血红蛋白含量(MCH)等贫血指标均显著低于对照组(P均<0.05)。女性患者RBC明显低于男性患者,广泛结肠炎患者RBC、HCT明显低于直肠炎和左半结肠炎患者,重度患者RBC、Hb、HCT明显低于轻度患者,差异均有统计学意义(P均<0.05)。RBC、Hb、HCT、MCH与临床疾病活动指标C反应蛋白(CRP)和(或)红细胞沉降率(ESR)呈显著负相关(P均<0.05)。结论:性别、病变范围、疾病活动性和病情严重程度是影响UC患者贫血发生的重要临床因素。Background:The prevalence of inflammatory bowel disease(IBD)is increasing worldwide,and anemia,one of the most prevalent extraintestinal manifestations of IBD,is still often underdiagnosed and undertreated.Aims:To analyze the correlations of clinical factors with anemia in patients with ulcerative colitis(UC).Methods:A retrospective analysis was conducted in 60 cases of UC admitted from September 2019 to May 2020 at the Second Affiliated Hospital of Zhengzhou University.Sixty healthy subjects were served as controls.Data of fasting venous blood sample analysis on admission were collected,and the correlations of indicators for anemia with the clinical factors were analyzed.Results:The indicators for anemia,including red blood cell(RBC)count,hemoglobin(Hb),hematocrit(HCT),mean corpuscular volume(MCV),mean corpuscular hemoglobin(MCH)etc.were significantly decreased in UC patients than in healthy controls(all P<0.05).RBC was lower in females than in males(P<0.05);RBC and HCT were lower in patients with pancolitis than in those with proctitis or left hemi-colon colitis(all P<0.05);RBC,Hb and HCT were lower in severe active UC than in mild active UC(all P<0.05).RBC,Hb,HCT and MCH were negatively correlated with two disease activity indicators for IBD,C-reactive protein(CRP)and/or erythrocyte sedimentation rate(ESR)(all P<0.05).Conclusions:Gender,as well as the disease extent,activity and severity are important clinical factors for anemia in patients with UC.

关 键 词：结肠炎 溃疡性 贫血 红细胞 血红蛋白 C反应蛋白 红细胞沉降率 

分 类 号：R44[医药卫生—诊断学]