中医药通过干预细胞自噬治疗纤维化疾病的研究进展  

Progress of the Treatment of Fibrosis by Autophagy with Traditional Chinese Medicine

作　　者：王瑞洁 段行武[1] 黄敏[1] 张润田[1] 姜文琦 高玥璇 陈曦[1] WANG Ruijie;DUAN Xingwu;HUANG Min;ZHANG Runtian;JIANG Wenqi;GAO Yuexuan;CHEN Xi(Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China)

机构地区：[1]北京中医药大学东直门医院,北京100700

出　　处：《世界中医药》2021年第20期3105-3110,共6页World Chinese Medicine

基　　金：国家自然科学基金青年科学基金项目(81804106)。

摘　　要：纤维化是指器官组织出现纤维结缔组织增多,实质细胞减少的现象。纤维化可发生于肺、心、肝、肾、皮肤等多处器官和组织,长期纤维化可导致其结构、功能的破坏和减退,严重时导致功能衰竭。研究表明,细胞自噬与纤维化疾病的发生、发展、转归过程有相关性,中医药治疗纤维化疾病疗效确切,其作用机制与细胞自噬及其相关因子或通路密切相关。现从对中医药通过干预细胞自噬过程,进而对维化疾病发挥治疗作用进行综述,以期深入挖掘中医药治疗纤维化疾病机制研究的新方向。Fibrosis refers to the increase of fibrous connective tissue and decrease of parenchymal cells in organ tissues,which occur in lungs,heart,liver,kidney,skin and other organs and tissues.Continuous progressive fibrosis can lead to structural damage and functional decline,or even functional failure.Studies show that autophagy is related to the occurrence,development and outcome of fibrotic diseases.The therapeutic effect of Traditional Chinese medicine(TCM)on fibrotic diseases is definite,and its mechanism is related to autophagy or pathway.The paper reviewed the treatment of fibrosis by autophagy with TCM,in order to exploring the new direction of TCM in the treatment of fibrotic diseases.

关 键 词：中医药 纤维化 细胞自噬 中药复方 中药单体 益气活血 病理机制 研究进展 

分 类 号：R259[医药卫生—中西医结合]