益生菌对阿尔兹海默病认知功能的影响  

Effect of probiotics on Alzheimer's disease:a meta-analysis

作　　者：李永红[1] 郑禄林 黄昶荃[2] LI Yonghong;ZHENG Lulin;HUANG Changquan(School of Electronic Engineering, Chengdu University of Information Technology, Chengdu 610225, China;Department of Gerontology, The Affiliated Hospital of Chongqing Medical University, Chongqing 400000, China)

机构地区：[1]成都信息工程大学电子工程学院,四川成都610225 [2]重庆医科大学附属医院老年科,重庆400000

出　　处：《西部医学》2021年第11期1637-1641,共5页Medical Journal of West China

基　　金：四川高等学校成果转化重大培育项目(2018Z060);成都市科技惠民技术研发项目(2015-HM01-00422-SF)。

摘　　要：目的评价服用益生菌对于阿尔兹海默病认知功能障碍患者认知和情绪的缓解效果。方法检索PubMed、中国知网等7个中英文数据库2021年5月1日前发表的通过服用益生菌改善认知或情绪的随机对照实验研究。根据纳入标准和排除标准筛选纳入文献,并对其进行质量评价。然后使用RevMan5.3对提取的数据作统计学分析。结果最终共有17篇文献纳入研究,其中有9篇文献质量较高。Meta分析结果显示,服用益生菌可以缓解认知功能障碍病程或使情绪乐观(RR=2.07,95%CI[1.79,2.39],I^(2)=79%),差异具有统计学意义(P<0.05)。结论阿尔兹海默病认知功能障碍患者服用益生菌对其认知功能改善具有积极的影响。Objective To evaluate the effect of probiotics on cognitive and emotional relief in patients with Alzheimer's disease or cognitive impairment.Methods Seven Chinese and English databases including PubMed and CNKI were searched for randomized controlled trials on improving cognition or emotion by taking probiotics published before May 1,2021.According to the inclusion criteria and exclusion criteria,the included literatures were screened and evaluated.Then Revman 5.3 was used to analyze the extracted data.Results A total of 17 articles were included in the study,of which 9 were of high quality.Meta analysis showed that probiotics could alleviate the course of cognitive impairment or make the mood optimistic(RR=2.07,95%CI[1.79,2.39],I^(2)=79%),the difference was statistically significant(P<0.05).Conclusion Probiotics have a positive effect on cognitive function in patients with cognitive impairment.

关 键 词：益生菌 阿尔兹海默病 肠道菌群 META分析 认知功能 

分 类 号：R459.3[医药卫生—治疗学]