异种(牛)脱细胞真皮基质原联合自体骨粉植入在开放式乳突根治术中的临床应用  

Clinical Application of Xenogenic Acellular(bovine)Dermal Matrix with Autologous Bone Powder Implantation in Open Mastoidectomy

作　　者：王莉竹 李书聆[1] 阮标[1] WANG Li-zhu;LI Shu-ling;RUAN Biao(Dept,of Otorhinolaryngology,The First Affiliated Hospital of Kunming Medical University,Kunming Yunnan 650032,China)

机构地区：[1]昆明医科大学第一附属医院耳鼻喉科,云南昆明650032

出　　处：《昆明医科大学学报》2021年第10期99-105,共7页Journal of Kunming Medical University

基　　金：云南省卫生科技计划基金资助项目(2018NS0156)。

摘　　要：目的旨在分析研究异种(牛)脱细胞真皮基质联合自体骨粉植入应用于开放式乳突根治术中,对患者术后快速干耳、上皮化、自体骨粉成活及降低术后感染机率的影响。方法收集自2016年9月至2020年9月间在昆明医科大学第一附属医院耳鼻喉Ⅰ科就诊并行手术治疗的中耳炎患者,将其根据本研究实验要求分为以下3组:(1)中耳炎患者中行开放式乳突根治术+异种(牛)脱细胞真皮基质联合自体骨粉植入的患者(实验组);(2)中耳炎行开放式乳突根治术+筋膜联合自体骨粉植入的患者(实验对照组);(3)中耳炎行开放式乳突根治术+筋膜置入(空白对照组);分别于术后2周、4周、6周、8周详细记录3组患者:(1)干耳;(2)上皮化;(3)骨粉是否成活;(4)是否感染4个方面。结果对术后2周、4周、6周3组间干耳发生率及术后4周、6周3组间上皮化发生率进行比较,术后2周、4周、6周实验组干耳发生率及术后4周、6周实验组上皮化发生率高于空白对照组与实验组对照组(P<0.05);而空白对照组与实验对照组比较无差异;3组间术后2周、4周、6周感染率比较差异无统计学意义(P>0.05)。对术后8周3组间干耳发生率、上皮化发生率、感染率进行比较,结果均为P>0.05,差异无统计学意义。结论异种(牛)脱细胞真皮基质联合自体骨粉植入应用于开放式乳突根治术中,术后能显著快速有效地缩短干耳时间,快速上皮化,于术后4~6周内能达到干耳、上皮化,确切保证植入的自体骨粉成活,从而有效降低了术后感染机率,最终提高远期疗效。Objective To investigate the application of xenogenic acellular(bovine)dermal matrix(ADM) combined with autologous bone powder implantation in open mastoidectomy,and investigate the effect on ear drying,epithelization,survival of autogenous bone meal and reduction of postoperative infection rate.Methods From September 2016 to September 2020,patients with otitis media who were treated by surgery in department I of Otolaryngology,First Affiliated Hospital of Kunming Medical University were divided into three groups according to the requirements of this study:(1)Patients with otitis media who underwent open radical mastoidectomy+xenogeneic(bovine)acellular dermal matrix combined with autologous bone meal implantation(experimental group);(2)Patients with otitis media underwent open radical mastoidectomy and fascia combined with autologous bone meal implantation(experimental control group);(3)Otitis media were treated with open radical mastoidectomy and fascia implantation(blank control group);At 2 weeks,4 weeks,6 weeks and 8 weeks after operation,the following four aspects were recorded:(1)dry ear;(2)epithelization;(3)survival of bone powder;(4)infection Results.After 2 weeks,4 weeks,6 weeks,the incidence of dry ear and the incidence of epithelization between 4 weeks,6 weeks after operation were compared.The chi square test showed that the results were P<0.001,which was statistically significant.The test level was adjusted and compared.Results The blank control group,the experimental control group and the experimental group were all P<0.001.The incidence of dry ear and epithelialization in the experimental group was higher than that in the blank control group and the experimental control group at 6 weeks and 4 and 6 weeks after operation,but there was no difference between the blank control group and the experimental control group;There was no significant difference in the infection rate among the three groups at 2,4 and 6 weeks after operation(P>0.05).The incidence of dry ear,epithelization and infection were compar

关 键 词：异种(牛)脱细胞真皮基质 干耳 上皮化 自体骨粉 感染 

分 类 号：R765[医药卫生—耳鼻咽喉科]