间充质干细胞对髓源性抑制细胞免疫应答负性调控作用的影响  

Effect of mesenchymal stem cells on negative regulation of immune response of myeloid-derived suppressor cells

作　　者：闵珂婷 张一国 杨浩 吕欣 Min Keting;Zhang Yiguo;Yang Hao;LüXin(Wannan Medical College,Wuhu 241002,Anhui Province,China;Shanghai Pulmonary Hospital of Tongji University,Shanghai 200433,China)

机构地区：[1]皖南医学院,安徽省芜湖市241002 [2]同济大学附属上海市肺科医院,上海市200433

出　　处：《中国组织工程研究》2022年第19期3084-3089,共6页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金(82000085),项目负责人:杨浩;国家自然科学基金(81871601),项目负责人:吕欣。

摘　　要：背景:髓源性抑制细胞是骨髓来源的一类异质性细胞群,能够抑制T细胞的功能,发挥免疫抑制作用。间充质干细胞是一种多能干细胞,可抑制先天性和适应性免疫反应。髓源性抑制细胞和间充质干细胞在免疫抑制功能上有许多相似之处,在肿瘤、炎症、移植等方面可产生相互联系。目的:综述基于髓源性抑制细胞的作用机制以及间充质干细胞对髓源性抑制细胞免疫应答负性调控作用的影响。方法:应用计算机检索Web of Science Core Collection数据库的相关文献,英文检索词为"Myeloid-derived suppressor cells""Mesenchymal stem cells""Stem cells",按纳入排除标准最终纳入49篇文献进行综述。结果与结论:髓源性抑制细胞通过分泌精氨酸酶1、诱导型一氧化氮合酶和吲哚胺2,3-双加氧酶等在体内发挥重要的免疫抑制功能。髓源性抑制细胞与间充质干细胞在自身免疫性疾病、器官移植、炎症感染、肿瘤等多种疾病治疗过程中通过不同机制相互作用,使肿瘤细胞逃避免疫监控,促进肿瘤进一步发展。在非肿瘤疾病中,髓源性抑制细胞发挥一定的良性调节作用,弱化机体自身的免疫反应,进而改善临床症状。BACKGROUND:Myeloid-derived suppressor cells are a heterogeneous group of cells derived from bone marrow,which can inhibit the function of T cells and exert immunosuppressive effect.Mesenchymal stem cells are pluripotent stem cells,which can inhibit innate and adaptive immune responses.Myeloid-derived suppressor cells and mesenchymal stem cells have many similarities in immunosuppressive function,which can be related to each other in tumor,inflammation and transplantation.OBJECTIVE:To summarize the mechanisms of action based on myeloid-derived suppressor cells and the effect of mesenchymal stem cells on the negative regulatory effect of immune response in myeloid-derived suppressor cells.METHODS:A computer search of the Web of Science Core Collection database was conducted with key words of"myeloid-derived suppressor cells","mesenchymal stem cells","stem cells".Finally,49 papers were included for review.RESULTS AND CONCLUSION:Myeloid-derived suppressor cells play an important immunosuppressive role in vivo by secreting arginase-1,inducible nitric oxide synthase,and indoleamine 2,3-dioxygenase.Myeloid-derived suppressor cells and mesenchymal stem cells interact through different mechanisms in the treatment of autoimmune diseases,organ transplantation,inflammatory infections,tumors and other diseases,causing tumor cells to evade immune surveillance and promoting further tumor progression.In non-tumor diseases,myeloid-derived suppressor cells play a certain benign regulatory role,weakening the body’s own immune response and improving clinical symptoms.

关 键 词：髓源性抑制细胞 间充质干细胞 免疫抑制 肿瘤 炎症 器官移植 综述 

分 类 号：R459.9[医药卫生—治疗学] R318[医药卫生—临床医学]