基因多态性对红细胞内多聚谷氨酸甲氨蝶呤浓度影响的研究进展  

Research Progress on the Effect of Genetic Polymorphisms on the Methotrexate Polyglutamates in Erythrocytes

作　　者：王培红[1] 张吟[1] 龚艳青 WANG Pei-hong;ZHANG Yin;GONG Yan-qing(The 2nd Affiliated Hospital of Fujian Medical University,Quanzhou 362000,China;High-tech Hospital,The 1st affiliated Hospital of Nanchang University,Nanchang 330096,China)

机构地区：[1]福建医科大学附属第二医院,福建泉州362000 [2]南昌大学第一附属医院高新医院,江西南昌330096

出　　处：《海峡药学》2021年第10期84-89,共6页Strait Pharmaceutical Journal

基　　金：2017年泉州市高层次人才项目(2017Z012)。

摘　　要：甲氨蝶呤(MTX)作为一种慢作用的抗风湿药,在临床上已普遍用于治疗类风湿性关节炎。MTX在体内主要是通过其活性代谢产物多聚谷氨酸甲氨蝶呤(MTXPGs)持续发挥药理效应,其与基因多态性的关系有少量报道,并且结果并不一致。因此本文就甲氨蝶呤相关基因多态性对红细胞内MTXPGs浓度影响作一综述,探索MTX疗效与红细胞内多聚谷氨酸甲氨蝶呤浓度和基因多态性的关系,以期为临床研究提供参考。Methotrexate(MTX),as a slow-acting anti-rheumatic drug,has been widely used clinically in the treatment of rheumatoid arthritis.It is mainly in the body through its active metabolite methotrexate polyglutamates(MTXPGs)continue to exert pharmacological effects.There are few reports on its relationship with gene polymorphism,and the results are not consistent.Therefore,this article reviewed the correlation between the concentrations of erythrocyte MTXPGs and methotrexate-related gene polymorphism,explores the relationship between MTX efficacy and the concentrations of erythrocyte MTXPGs and gene polymorphism,with a view to provide reference for clinical research.

关 键 词：甲氨蝶呤 类风湿性关节炎 基因多态性 多聚谷氨酸甲氨蝶呤 

分 类 号：R969.4[医药卫生—药理学]