聚乙二醇甲基丙烯酸酯聚合物刷 接枝医用功能纸制备及生物相容性研究  

Preparation of PEGMA Polymer Brush Grafted Medical Functional Paper and Its Biocompatibility

作　　者：吕文志 周小凡[2] 王润平 王国莲 杨灶银 罗美分 Lv Wenzhi;Zhou Xiaofan;Wang Runping;Wang Guolian;Yang Zaoyin;Luo Meifen(College of Chemistry and Chemical Engineering of Qiannan Normal University for Nationalities,Duyun 558000,Guizhou,China;National and Local Joint Engineering Center of Biomass Materials for Packaging Mechanical and Electrical Products,Nanjing Forestry University,Nanjing 210037,China)

机构地区：[1]黔南民族师范学院化学化工学院,贵州都匀558000 [2]南京林业大学机电产品包装生物质材料国家地方联合工程中心,南京210037

出　　处：《中华纸业》2021年第22期10-15,共6页China Pulp & Paper Industry

基　　金：贵州省科技支撑计划项目(黔科合支撑[2019]2860号);贵州省教育厅科技拔尖人才支持计划项目(黔教合KY字[2018]079);贵州省教育厅自然科学基金青年项目(黔教合KY字[2017]355);“大学生创新创业训练计划”项目(NO:202110670040)。

摘　　要：为改善纤维素基纸张材料的生物相容性,本研究通过表面引发原子转移自由基聚合技术,将聚乙二醇甲基丙烯酸酯聚合物刷接枝到纸张表面制备医用功能纸,并对聚乙二醇甲基丙烯酸酯聚合物刷在纸张表面的接枝效率及其生物相容性进行了研究。结果表明:采用表面引发原子转移自由基聚合技术可有效地将聚乙二醇甲基丙烯酸酯聚合物刷接枝到纸张表面,且整个接枝过程活性可控;相比原纸,接枝聚乙二醇甲基丙烯酸酯聚合物刷纸张的抗血细胞黏附能力明显增强,补体激活显著改善,细胞毒性显著降低,呈现出良好的生物相容性。In order to improve the biocompatibility of cellulose based paper mat erials,medical functional paper was prepared by grafting polyethylene glycol m ethacrylate(PEGMA)polymer brushes onto the surface of paper via surface init iated atom transfer radical polymerization(ATRP)technique.Then the grafting efficiency of PEGMA polymer brushes on the surface of paper and their biocompatibility were investigated.Results showed that the grafting of PEGMA polym er brushes onto the surface of the paper was effective by using ATRP technique,and the activity of the whole grafting process was controllable.Results show tha t compared with the original paper,blood cell adhesion,complement activation and cytotoxicity of PEGMA polymer brush grafted paper shows better biocomp atibility.

关 键 词：医用功能纸 聚乙二醇甲基丙烯酸酯 聚合物刷 原子转移自由基聚合 生物相容性 

分 类 号：TS727.3[轻工技术与工程—制浆造纸工程] TB34[一般工业技术—材料科学与工程]