雌激素对Treg细胞的影响机制研究进展  

Advances in mechanism of estrogen’s effect on Treg cells

作　　者：徐一君 邓勇志 XU Yi-Jun;DENG Yong-Zhi(Department of Cardiovascular Surgery,Shanxi Cardiovascular Disease Hospital,Taiyuan 030024,China)

机构地区：[1]山西省心血管病医院心血管外科,太原030024

出　　处：《中国免疫学杂志》2021年第21期2597-2601,共5页Chinese Journal of Immunology

基　　金：山西省卫生厅科技攻关基金资助项目(2017104);山西省心血管病医院科研激励计划项目(XYS20170305)资助。

摘　　要：雌激素是一种维持机体正常生理功能的类固醇激素,其主要功能包括促进生殖系统发育,调节机体代谢水平及免疫功能。研究发现,雌激素对多种自身免疫耐受疾病有较好的治疗效果。Treg在保持自身免疫耐受方面具有重要作用,其功能的缺陷将导致自身免疫耐受性的破坏和自身免疫性疾病的发生。本文就雌激素对Treg细胞影响机制的研究进展做一简要综述。Estrogen is a steroid hormone that maintains the body’s normal physiological functions.Main functions of estrogen include promoting development of reproductive system,regulating metabolism and immune function.Studies have found that estrogen has better therapeutic effect on a variety of autoimmune diseases.Treg plays an important role in maintaining autoimmune tolerance,and its functional defects will lead to destruction of autoimmune tolerance and occurrence of autoimmune diseases.In this review,mechanism of estrogen’s effect on Treg cells was reviewed.

关 键 词：雌激素 TREG细胞 免疫耐受 

分 类 号：R392.4[医药卫生—免疫学]