抑制素B及性激素指标检测在男性生精功能中的应用  

Application of detecting inhibin B and sex hormone indicators in male spermatogenesis function

作　　者：张琴[1] 苏占营[2] 吴成亮[2] 辜敏[2] 江旺航 ZHANG Qin;SU Zhanying;WU Chengliang;GU Min;JIANG Wanghang(Department of Clinical Laboratory,Jiujiang Municipal Maternal and Child Health Care Hospital,Jiujiang,Jiangxi 332000,China;Department of Assisted Reproduction,Jiujiang Municipal Maternal and Child Health Care Hospital,Jiujiang,Jiangxi 332000,China)

机构地区：[1]江西省九江市妇幼保健院检验科,江西九江332000 [2]江西省九江市妇幼保健院辅助生殖科,江西九江332000

出　　处：《检验医学与临床》2021年第22期3237-3239,3243,共4页Laboratory Medicine and Clinic

基　　金：江西省科技厅课题(20171BBG70010);江西省卫生健康委员会基金项目(20204241)。

摘　　要：目的探讨抑制素B(INH-B)及血清性激素在男性睾丸生精功能中的作用,了解血清及精浆INH-B水平与精子生发的关系。方法回顾性分析2018年1月至2020年12月在该院接受辅助生殖技术治疗的316例男性患者资料,根据精液浓度将其分为4组:浓度正常组(A组,80例)、轻中度少精子组(B组,104例)、严重少精子组(C组,78例)、无精子症组(D组,54例);根据无精子症原因将D组分为梗阻性无精子症(OA)组(34例)及非梗阻性无精子症(NOA)组(20例)。检测各组血清INH-B、精浆INH-B、卵泡刺激素(FSH)、黄体生成素(LH)、睾酮(T)水平。结果A组的精浆INH-B水平显著高于其余各组(P<0.05);C组和NOA组血清INH-B水平显著低于A组及OA组(P<0.05);血清INH-B水平与血清FSH及LH水平呈负相关(P<0.05);精浆INH-B水平与血清T水平呈正相关(P<0.05)。结论血清INH-B水平和性激素呈现一定的关联性,且INH-B和性激素均直接影响精子的生成,可将INH-B作为评价生精功能的参考指标。临床上可以将INH-B作为预测不同病因的无精子症患者睾丸活检取精结局的指标。Objective To investigate the role of inhibin B(INH-B)and serum sex hormone levels in male testicular spermatogenesis function,and to understand the relationship between serum and seminal plasma INH-B levels with spermatogenesis.Methods The data of 316 male patients receiving the assisted reproductive technology treatment in this hospital from January 2018 to December 2020 were retrospectively analyzed.According to semen concentration,they were divided into 4 groups:the normal concentration group(A group,80 cases),the mild to moderate oligozoospermia group(B group,104 cases),the severe oligospermia group(C group,78 cases)and the azoospermia group(D group,54 cases).And according to the causes of azoospermia,the D group was divided into the obstructive azoospermia group(OA group,34 cases)and non-obstructive azoospermia group(NOA group,20 cases).Finally,the levels of serum INH-B,seminal plasma INH-B,FSH,LH,T were measured in each group.Results The level of semen INH-B in the A group was significantly higher than that in the other groups(P<0.05).And the level of serum INH-B of the C group and NOA group was significantly lower than that in the A group and OA group(P<0.05).The level of serum INH-B was negatively correlated with serum FSH and LH levels(P<0.05).And the level of seminal INH-B was positively correlated with the serum T level(P<0.05).Conclusion The level of serum INH-B has a certain correlation with sex hormones,moreover INH-B and sex hormones directly influence the generation of sperms,and INH-B can serve as the reference indicator for evaluating the spermatogenesis function.In clinic,INH-B can serve as the indicator for predicting the outcome of testicular sperm biopsy in the patients with different etiologies of azoospermia.

关 键 词：抑制素B 男性不育 性激素 无精子症 

分 类 号：R698.2[医药卫生—泌尿科学]