1935例妊娠期女性阴道微生态及B族链球菌检测结果分析  

Analysis on detection results of vaginal microecology and group B streptococci in 1935 pregnant females

作　　者：邱德稳 钟师 汤旭[1] 曾辛[1] QIU Dewen;ZHONG Shi;TANG Xu;ZENG Xin(Department of Clinical Laboratory,Jiangxi Provincial Maternal and Child Health Care Hospital,Nanchang,Jiangxi 330006,China)

机构地区：[1]江西省妇幼保健院检验科,江西南昌330006

出　　处：《检验医学与临床》2021年第22期3274-3277,共4页Laboratory Medicine and Clinic

摘　　要：目的探讨妊娠期女性阴道微生态及B族链球菌(GBS)的定植状况。方法选取2019年7月至2020年6月在该院产科门诊就诊的1935例妊娠期女性为研究对象,分别行盐水湿片显微镜镜检和comet-800阴道微生态检测分析系统检测,根据相关标准进行微生态评价,采用荧光定量PCR检测GBS感染情况。分别按孕周、年龄、GBS感染情况分组,分析比较各组阴道微生态的状况以及不同类型疾病的感染情况。结果所检标本中阴道微生态失衡者556例,占28.7%,其中假丝酵母菌阴道病(VVC)的感染率最高(15.7%)。不同孕期的妊娠期女性阴道微生态失衡率(孕早期18.57%、孕中期30.25%、孕晚期37.41%)比较,差异有统计学意义(P<0.05);不同孕期女性细菌性阴道病(BV)、VVC的感染率比较,差异有统计学意义(P<0.05)。各年龄组妊娠期女性阴道微生态失衡率差异无统计学意义(P>0.05)。所检标本中GBS阳性者135例,占7.0%;所有GBS阳性者阴道微生态均失衡;GBS阴性者中阴道微生态失衡421例,占21.8%。结论妊娠期女性GBS感染可造成阴道微生态失衡,以VVC感染为主;妊娠期存在较高的阴道微生态失衡率,其中孕晚期的失衡率最高,感染率以VVC最高;年龄不是影响妊娠期女性阴道微生态失衡的主要因素。Objective To investigate the microecology of vagina in pregnant women and the colonization of group B streptococci(GBS).Methods A total of 1935 pregnant women visiting in the obstetric clinic of this hospital from July 2019 to June 2020 were selected as the research subjects,and underwent the detection by the saline wet film microscopic examination and comet-800 vaginal microecological examination and analysis system.The micro-ecological evaluation was conducted according to the relevant standards.The GBS infection situation was detected by the fluorescent quantitative PCR.All the research subjects were grouped according to the pregnant weeks,age and GBS infection status.Then the vaginal microecological situation and the infection situation of different types of disease were analyzed and compared among the groups.Results Among the detected specimens,there were 556 cases of vaginal microecological imbalance,accounting for 28.7%.Among them,the infection rate of candida vaginosis(VVC)was the highest(15.7%).The vaginal microecological imbalance rates(18.57%in the early pregnancy,30.25%in the middle pregnancy,and 37.41%in the late pregnancy)had statistically significant difference among different pregnancy periods of pregnant females(P<0.05);there were differences in the infection rates of bacterial vaginosis(BV)and VVC among different pregnant periods(P<0.05).There was no statistically significant difference in the vaginal microecological imbalance rate among different age groups of pregnant females(P>0.05).In the examined specimens,there were 135 cases of GBS positive,accounting for 7.0%;all cases of GBS positive were unbalanced in vaginal microecology;among the cases of GBS negative,there were 421 cases of vaginal microecology imbalance,accounting for 21.8%.Conclusion GBS infection in pregnant females can cause the vaginal microecological imbalance,which is dominated by VVC infection;there is a higher vaginal microecological imbalance rate during pregnancy,in which the imbalance rate in the late pregnancy is the hi

关 键 词：生殖道微生态 B族链球菌 需氧菌性阴道病 细菌性阴道病 

分 类 号：R711.31[医药卫生—妇产科学]