2型糖尿病女性患者并发大血管病变的影响因素  

Influencing factors of type 2 diabetes mellitus female patients with macroangiopathy lesion

作　　者：马艳荣[1] 王新玲[1] 周忠凯[1] 马福慧[1] 郭艳英[1] Ma Yanrong;Wang Xinling;Zhou Zhongkai;Ma Fuhui;Guo Yanying(Department of Endocrinology,People's Hospital of Xinjiang Uygur Autonomous Region,Urumqi 830001,Xinjiang,China)

机构地区：[1]新疆维吾尔自治区人民医院内分泌科,新疆乌鲁木齐830001

出　　处：《血管与腔内血管外科杂志》2021年第4期387-392,共6页Journal of Vascular and Endovascular Surgery

基　　金：自治区科技支疆项目计划(指令性)项目(2019E0285)。

摘　　要：目的探讨2型糖尿病(T2DM)女性患者并发大血管(MV)病变的影响因素。方法收集2018年1月至2021年1月在新疆维吾尔自治区人民医院接受治疗的202例T2DM女性患者的临床资料,根据是否并发MV病变将患者分为单纯组(n=69)与MV组(n=133)。分析T2DM女性患者并发MV病变的影响因素。结果单因素分析结果显示,MV组和单纯组患者的年龄、病程、合并糖尿病视网膜病变情况、收缩压、舒张压、胰岛素抵抗指数(HOMA-IR)、股骨颈骨密度(BMD)、促甲状腺素(TSH)、肌酐(Cre)水平比较,差异均有统计学意义(P<0.05)。多因素分析结果显示,年龄、病程、合并糖尿病视网膜病变、收缩压、舒张压、HOMA-IR、TSH、Cre水平是T2DM女性患者并发MV病变的危险因素,股骨颈BMD维持在较高水平是T2DM女性患者并发MV病变的保护因素(P<0.05)。结论年龄、病程、合并糖尿病视网膜病变情况、收缩压、舒张压、HOMA-IR、TSH、Cre是T2DM女性患者并发MV病变的危险因素,而股骨颈BMD维持在较高水平是T2DM女性患者并发MV病变的保护因素。针对上述危险因素进行早期监测,并给予积极干预能够降低T2DM女性患者并发MV病变的风险。Objective To investigate the risk factors of type 2 diabetes mellitus(T2DM)in female patients combined with macrovascular(MV)lesion.Method The clinical data of 202 patients with T2DM who were treated in the People's Hospital of Xinjiang Uygur Autonomous Region from January 2018 to January 2021 were collected,and the subjects were divided into a single group and a macrovascular(MV)group according to whether they were combined with MV.The risk factors of T2DM female patients with MV lesion were analyzed.Result The results of the univariate analysis indicated that the age,disease course,diabetic retinopathy,systolic blood pressure,diastolic blood pressure,(homeostasis model-insulin resistance)HOMA-IR,femoral neck bone mineral density(BMD),thyroid stimulating hormone(TSH),creatinine(Cre),and the number of cervical plaques in the MV group and the single group were all statistical significant different(P<0.05).The results of the multivariate analysis illustrated that the age,disease course,diabetic retinopathy,systolic blood pressure,diastolic blood pressure,HOMA-IR,TSH and Cre were independent risk factors for T2DM with MV lesion(P<0.05).Femoral neck BMD sustaining a high level was proved as a protective factor for T2DM with MV lesion(P<0.05).Conclusion Age,disease course,diabetic retinopathy,systolic blood pressure,diastolic blood pressure,HOMA-IR,TSH and Cre were risk factors for T2DM with MV.A high level of femoral neck BMD is a protective factor for T2DM with MV lesion.Early screening of the foregoing risk factors and active intervention could reduce the risk of MV lesion combined with T2DM.

关 键 词：2型糖尿病 大血管病变 并发症 危险因素 

分 类 号：R543[医药卫生—心血管疾病]