肌源干细胞在周围神经再生中的潜力  

Potential of muscle-derived stem cells in peripheral nerve regeneration

作　　者：安维政 何萧 任帅 刘建宇[1] An Weizheng;He Xiao;Ren Shuai;Liu Jianyu(First Department of Orthopedics,The Second Affiliated Hospital of Harbin Medical University,Harbin 150000,Heilongjiang Province,China)

机构地区：[1]哈尔滨医科大学附属第二医院骨一科,黑龙江省哈尔滨市150000

出　　处：《中国组织工程研究》2022年第7期1130-1136,共7页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金(81971828),项目负责人:刘建宇。

摘　　要：背景:肌源性干细胞具有强大的自我更新和多向分化潜能,在神经损伤修复领域具有广泛应用前景。目的:文章就周围神经损伤的治疗现状和肌源干细胞治疗周围神经损伤的研究进展进行综述。方法:以“肌源干细胞,周围神经损伤,组织工程,许旺细胞,移植,再生,神经导管”或“muscle-derived stem cell,peripheral nerve injury,tissue engineering,Schwann cells,transplant,regeneration,nerve conduit”为检索词,检索PubMed、CNKI、万方数据库,排除重复性研究以及内容不相关的文献,最后纳入100篇文献进行综述。结果与结论:肌源干细胞通过分化为神经再生所需要的各种支持细胞和强大的旁分泌作用,在修复神经损伤等方面表现出良好的再生潜力。BACKGROUND:Muscle-derived stem cells have strong self-renewal and multi-directional differentiation potential,which has a wide application prospect in the field of nerve injury repair.OBJECTIVE:To review the treatment status of peripheral nerve injury and research progress of muscle-derived stem cells in the treatment of peripheral nerve injury.METHODS:“Muscle-derived stem cell,peripheral nerve injury,tissue engineering,Schwann cell,transplant,regeneration,nerve conduit”were the search words.The articles in PubMed,CNKI and Wanfang databases were cross-searched.After excluding repetitive research and irrelevant articles,100 articles were finally included for review.RESULTS AND CONCLUSION:Muscle-derived stem cells show good regenerative potential in repairing nerve injury by differentiating into various kinds of support cells needed for nerve regeneration and powerful secretory function.

关 键 词：肌源干细胞 周围神经损伤 许旺细胞 移植 神经导管 再生 神经营养因子 组织工程 分化 综述 

分 类 号：R459.9[医药卫生—治疗学] R394.2[医药卫生—临床医学]