脊髓损伤后室管膜区内源性神经干细胞反应的系列问题  

Serial questions about endogenous neural stem cell response in the ependymal zone after spinal cord injury

作　　者：范一鸣 刘方煜 张洪宇 李帅[1] 王岩松 Fan Yiming;Liu Fangyu;Zhang Hongyu;Li Shuai;Wang Yansong(Fifth Department of Orthopedics,the First Affiliated Hospital of Harbin Medical University,Harbin 150000,Heilongjiang Province,China)

机构地区：[1]哈尔滨医科大学附属第一医院骨五科,黑龙江省哈尔滨市150000

出　　处：《中国组织工程研究》2022年第7期1137-1142,共6页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金项目(81871781),项目负责人:王岩松。

摘　　要：背景:脊髓损伤是中枢神经系统的严重损伤,目前尚未有一种有效的方法可以将其治愈。脊髓损伤患者在生理和心理上都承受巨大的痛苦,而高昂的治疗费用以及严重的后遗症,已成为患病家庭的主要负担。随着对内源性神经干细胞分子生物学研究的不断发展,研究发现利用内源性神经干细胞修复受损脊髓传导束有巨大潜力,这也为重建功能神经环路带来了希望。目的:综述脊髓损伤后内源性神经干细胞如何反应及其调控因素。方法:检索PubMed、Web of Science数据库及万方、CNKI中国期刊全文数据库收录的脊髓损伤后内源性神经干细胞反应的相关文章,英文检索词为“spinal cord injury,endogenous neural stem cell”,中文检索词为“脊髓损伤,内源性神经干细胞”,按纳入和排除标准共纳入70篇文献进行归纳总结。结果与结论:脊髓损伤后室管膜区的内源性神经干细胞被激活,迁移至受损部位,分化为功能性神经元及胶质细胞,限制损伤进一步扩大,修复受损的神经结构,这一过程受到了继发性脊髓损伤时释放的多种因子的影响,而对于内源性神经干细胞的来源及其被激活的机制,以及如何诱导其向更利于修复脊髓损伤的方向分化仍需要更深一步的研究。BACKGROUND:Spinal cord injury is a serious injury to the central nervous system,and there is currently no effective treatment for it.Patients with spinal cord injury suffer great pain both physically and mentally.The high cost of treatment and serious sequelae have become the main burden of sick families.With the continuous development of molecular biology research on endogenous neural stem cells,it is found that endogenous neural stem cells have great potential to repair damaged spinal cord conduction bundle,which also brings hope for the reconstruction of functional nerve loop.OBJECTIVE:To review the response and regulatory factors of endogenous neural stem cells after spinal cord injury.METHODS:PubMed,Web of Science,Wanfang,CNKI China journal full-text database were searched for articles regarding endogenous neural stem cells after spinal cord injury.English and Chinese search terms were“spinal cord injury,endogenous neural stem cell”.According to inclusion and exclusion criteria,70 articles were included for summary.RESULTS AND CONCLUSION:After spinal cord injury,endogenous neural stem cells in the ependymal region were activated,migrated to the damaged site,differentiated into functional neurons and glial cells,limited the further expansion of the injury,and repaired the damaged neural structure.This process is influenced by a variety of factors released during secondary spinal cord injury.Further research is needed on the origin of endogenous neural stem cells and the mechanisms by which they are activated,as well as how they can be induced to differentiate in a direction more conducive to repair of spinal cord injury.

关 键 词：干细胞 神经干细胞 内源性 脊髓损伤 继发性脊髓损伤 室管膜细胞 综述 

分 类 号：R459.9[医药卫生—治疗学] R318[医药卫生—临床医学]