天然及复合海藻酸盐水凝胶改性和构建复合体系修复骨缺损  

Modification of natural and composite alginate hydrogels and repair of bone defect with composite systems

作　　者：范谊 刘亚东[1] 崔宇韬 刘贺[1] 田宇航 李少荣 王淦 吴丹凯[1] 彭传刚[1] Fan Yi;Liu Yadong;Cui Yutao;Liu He;Tian Yuhang;Li Shaorong;Wang Gan;Wu Dankai;Peng Chuangang(Department of Orthopedics,Second Hospital of Jilin University,Changchun 130041,Jilin Province,China)

机构地区：[1]吉林大学第二医院骨科,吉林省长春市130041

出　　处：《中国组织工程研究》2022年第28期4532-4538,共7页Chinese Journal of Tissue Engineering Research

基　　金：吉林省财政厅项目(2019SCZT014),项目负责人:吴丹凯;吉林省科技厅项目(20200404140YY),项目负责人:吴丹凯;国家自然科学基金项目(81772456),项目主要参与人:刘贺。

摘　　要：背景:作为一种骨组织工程的细胞支架材料,海藻酸盐水凝胶因其良好的生物相容性、可再生的特点受到关注,然而天然海藻酸盐水凝胶因降解缓慢、凝胶不稳定等缺陷使其在机体环境下可能无法实现预期的效果。因此,需要对天然海藻酸盐水凝胶进行改性及构建复合体系,以满足骨缺损修复所需的功能。目的:介绍天然海藻酸盐水凝胶的结构及其改性策略,复合海藻酸盐水凝胶的构建策略,强调在不同的骨缺损修复中海藻酸盐水凝胶及其复合体系所需具备的各种功能,并总结当前的研究重点和展望未来的发展趋势。方法:作者以“alginate hydrogel、bone defect、bone repair、海藻酸盐、骨缺损、骨修复”为检索词,检索1995-2021年PubMed、Web of Science、Medline、万方、中国知网和维普数据库中的相关文献,筛选后对69篇文献进行分析。结果与结论:①海藻酸盐水凝胶通过氧化及γ射线照射等处理,能够获得更快的生物降解性能,而不同的交联方式可以使其具有不同的化学结构。②通过复合体系的构建,海藻酸盐水凝胶及其复合体系能够作为细胞、生物活性因子及药物的载体,可以单独或者联合其他支架使用。③因为具备以上复杂的性能,海藻酸盐水凝胶及其复合体系在骨缺损修复中表现出良好的前景,在部分已有的研究报道中,实现了临界性骨缺损的完全骨桥接。海藻酸盐复合体系为骨修复提供了潜在的解决方案,即通过局部生物活性物质的控制性递送,实现骨缺损的加速愈合以及临界性骨缺损的愈合。④在大节段及承重骨缺损的修复中,可以联合其他高机械强度的支架,在提供机械承重的同时,增强了其他支架的骨整合能力,而这些方案能够适应不同的骨缺损修复的要求。⑤总体而言,海藻酸盐水凝胶及其复合体系在动物实验中已经显现出良好的促进骨组织修复效果,为骨组织BACKGROUND:As a cell scaffold material for bone tissue engineering,alginate hydrogel has attracted attention due to its good biocompatibility and renewable characteristics.However,due to the slow degradation and instability of natural alginate hydrogel,it may not achieve the desired effect in the body environment.Therefore,modification of natural alginate hydrogel and construction of its composite system are needed to meet the needs of bone repair.OBJECTIVE:To introduce the structure and modification strategy of natural alginate hydrogel,and the construction strategy of composite alginate hydrogel.It emphasizes the various functions of alginate hydrogel and its composite system in different bone defect repair,and summarizes the current research focus and prospects the future development trend.METHODS:With“alginate hydrogel,bone defect,bone repair,alginate,bone defect,bone repair”as the key words,the author searched related articles on PubMed,Web of Science,Medline,Wanfang,CNKI and VIP databases from 1995 to 2021.Totally 69 articles were analyzed after screening.RESULTS AND CONCLUSION:(1)Through oxidation,γ-ray irradiation and other treatments,alginate hydrogel can achieve faster biodegradability,and different crosslinking methods can make it have different chemical structures.(2)Through the construction of the composite system,the alginate hydrogel and the composite system can be used as carriers for cells,bioactive factors and drugs,and can be used alone or in combination with other stents.(3)Due to the above complex properties,alginate gel and its composite system have a good prospect in the repair of bone defects,and in some existing research reports,complete bone bridging of critical bone defects has been achieved.Alginate hydrogel composite systems provide potential solutions for bone repair.Accelerated healing of bone defects and critical bone defect healing are achieved through controlled delivery of local bioactive substances.(4)In the repair of large segment and load-bearing bone defects,other scaff

关 键 词：海藻酸盐水凝胶 海藻酸盐 水凝胶 骨缺损 骨修复 骨组织工程 生物材料 综述 

分 类 号：R459.9[医药卫生—治疗学] R363[医药卫生—临床医学]