无机纳米填料对植入硅橡胶生物相容性的影响  

Influence of inorganic nano-fillers on the biocompatibility of implanted silicone rubber

作　　者：田由京 石书萍 吴幸[1] Tian Youjing;Shi Shuping;Wu Xing(Department of General Surgery,First Affiliated Hospital of Hainan Medical College,Haikou 570102,Hainan Province,China;Department of Neurosurgery,First Affiliated Hospital of Hainan Medical College,Haikou 570102,Hainan Province,China)

机构地区：[1]海南医学院第一附属医院普通外科,海南省海口市570102 [2]海南医学院第一附属医院神经外科,海南省海口市570102

出　　处：《中国组织工程研究》2022年第28期4581-4586,共6页Chinese Journal of Tissue Engineering Research

基　　金：海南省自然科学基金项目(20158286),项目负责人:吴幸。

摘　　要：背景:硅橡胶是人体组织、器官外科修复重建的常用生物材料,但其自身存在生物相容性缺陷,无机纳米填料为植入硅橡胶的生物相容性改良和构建具有特定功能的复合材料提供了新契机。目的:综述植入硅橡胶添加无机纳米填料改性在生物相容改良研究方面已取得的成果及不足。方法:在PubMed、Web of Science和Medline等英文生物医学数据库,输入“siloxane,silicone rubber,inorganic nano-filler,metal nano-filler,metal oxide nano-filler,carbon nanoparticles”关键词,在万方、CNKI和维普等中文数据库输入“硅橡胶、无机纳米填料、纳米金属、纳米金属氧化物、纳米碳”关键词,分别检索出与无机纳米填料改性硅橡胶的相关文献,时间跨度从2014年1月至2020年10月。结果与结论:利用纳米金属及其氧化物和纳米新碳填料对植入硅橡胶本体或表面进行改性,增进了硅橡胶的生物相容性,可在细胞生长、抗凝血、表面特性、力学性能、耐久性、抗感染功能化等方面产生积极影响。未来需研究不同纳米填料对硅橡胶表面性质(如拓扑结构、电荷、湿润性)造成的细胞增殖移行机制、纳米金属杀菌剂在硅橡胶表面控释阳离子的细菌-纳米粒子相互作用调节策略,以及植入后潜在的纳米毒性。BACKGROUND:Silicone rubber is a common biological material for surgical repair and reconstruction of human tissues and organs.Due to the shortcomings of silicone rubber’s own biocompatibility,inorganic nano-fillers provide new opportunities for the biocompatibility improvement of implanted silicone rubber and the construction of composite materials with specific functions.OBJECTIVE:To review the achievements and deficiencies in the research on biocompatibility of implanted silicone rubber by adding inorganic nano-fillers.METHODS:To enter the keywords“siloxane,silicone rubber,inorganic nano-filler,metal nano-filler,metal oxide nano-filler,carbon nanoparticles”on English biomedical databases PubMed,Web of Science and Medline,and those in Chinese with same meaning as English on Chinese databases Wanfang,CNKI and VIP,to harvest the related articles on inorganic nano-filler modified silicone rubber.The time span was from January 2014 to October 2020.RESULTS AND CONCLUSION:Metal and their oxide nanoparticles as well as new carbon nano-fillers can improve the biocompatibility of the implanted silicone rubber by body or surface modification,which have a positive impact in the aspects of cell growth,anticoagulation,surface properties,mechanical properties,durability,anti-infective functionalization and so on.In the future,it is necessary to study the mechanism of cell proliferation and migration caused by different nano-fillers on the surface properties of silicone rubber,such as topological structure,charge,and wettability,the regulation strategies and planting of nano-metal bactericides to control the release of cations on the surface of silicone rubber,also the potential nano-toxicity after being implanted.

关 键 词：硅橡胶 无机纳米填料 纳米金属 纳米金属氧化物 纳米碳 碳离子 碳纳米管 石墨烯 

分 类 号：R459.9[医药卫生—治疗学] R318.08[医药卫生—临床医学]