Forsterite-hydroxyapatite composite scaffolds with photothermal antibacterial activity for bone repair  

作　　者：Weiye LIU Rongtai ZUO Tanglong ZHU Min ZHU Shichang ZHAO Yufang ZHU 

机构地区：[1]School of Materials Science and Engineerings University of Shanghai for Science and Technology,Shanghai 200093,China [2]State Key L aboratory of High Performance Ceramics and Superfine Microstructure,Shanghai Institute of Ceramics,Chinese Academy of Sciences,Shanghai 200050,China [3]Department of Orthopedics,Shanghai Jiao Tong University affiliated Sixth People s Hospital,Shanghai Jiao Tong University,Shanghai 200233,China

出　　处：《Journal of Advanced Ceramics》2021年第5期1095-1106,共12页先进陶瓷（英文）

基　　金：supported by the National Natural Science Foundation of China(Nos.51872185,51972212,and 52072246);Shanghai Natural Science Foundation(No.19ZR1435100).

摘　　要：Bone engineering scaffolds with antibacterial activity satisfy the repair of bacterial infected bone defects,which is an expected issue in clinical.In this work,3D-printed polymer-derived forsterite scaffolds were proposed to be deposited with hydroxyapatite(HA)coating via a hydrothermal treatment,achieving the functions of photothermal-induced antibacterial ability and bioactivity.The results showed that polymer-derived forsterite scaffolds possessed the photothermal antibacterial ability to inhibit Staphylococcus aureus(S.aureus)and Escherichia coli(E.coli)in vitro,owing to the photothermal effect of free carbon embedded in the scaffolds.The morphology of HA coating on forsterite scaffolds could be controlled through changing the hydrothermal temperature and the pH value of the reaction solution during hydrothermal treatment.Furthermore,HA coating did not influence the mechanical strength and photothermal effect of the scaffolds,but facilitated the proliferation and osteogenic differentiation of rat bone mesenchymal stem cells(rBMSCs)on scaffolds.Hence,the HA-deposited forsterite scaffolds would be greatly promising for repairing bacterial infected bone defects.

关 键 词：forsterite scaffolds hydroxyapatite(HA)coating bone repair photothermal effect antibacterial activity 

分 类 号：TB306[一般工业技术—材料科学与工程] R318.08[医药卫生—生物医学工程]