离子液体氢键及生物医药应用  

Hydrogen-bond in ionic liquids and its application in biomedicine

作　　者：董坤[1] 张锁江[1] Kun Dong;Suojiang Zhang(Institute of Process Engineering,Chinese Academy of Sciences,Beijing 100190,China)

机构地区：[1]中国科学院过程工程研究所,北京100190

出　　处：《中国科学：化学》2021年第10期1425-1434,共10页SCIENTIA SINICA Chimica

基　　金：国家自然科学基金重大项目(编号:21890762);国家自然科学基金面上项目(编号:21878296)资助。

摘　　要：离子液体在生物医药领域展现了巨大的应用潜力,同时这也是离子液体研究的前沿领域.然而生物相容性机理和药物构效关系不清楚,成为离子液体生物医药应用的瓶颈问题.离子间特殊氢键作用,提供了揭示其生物机理的分子基础.本文通过3个典型应用实例,即DNA稳定、抗肿瘤治疗和药物合成,阐述了氢键在离子液体生物医药应用过程中起到的关键作用,这些结论将为开拓新的离子液体生物医药应用提供科学依据.Ionic liquids(ILs) have shown great application potential and drawn broad interests in the field of biomedicine. Despite some important progress, the study of the bio. compatibility and the structure-activity relationship of ILs has just started, and the mechanism is completely unclear, which is a bottleneck in its biological applications. The hydrogen-bonds between ions have become the molecular basis for revealing the biological mechanism. This work introduces the latest development of ILs in biomedicine fields by three typical examples, DNA stabilization, anti-tumor therapy, and API-ILs drug synthesis, recrystallization and release, and details the principle and pathological effects of the hydrogen-bonds. These conclusions can provide knowledge basis for the development of new ILs biomedicine applications.

关 键 词：离子液体 氢键作用 DNA稳定 抗肿瘤治疗 离子液体药物 

分 类 号：O645.1[理学—物理化学] TQ460.1[理学—化学]