规范化治疗妊娠合并甲亢对妊娠结局的影响  

Effect of Standardized Treatment of Pregnancy Complicated with Hyperthyroidism on Pregnancy Outcome

作　　者：齐慧超 QI Huichao(Obstetrics and Gynecology,Fuxin Second People's Hospital(Fuxin Maternity Hospital),Fuxin 123000,China)

机构地区：[1]阜新市第二人民医院(阜新市妇产医院)妇产科,辽宁阜新123000

出　　处：《中国医药指南》2021年第31期61-63,共3页Guide of China Medicine

摘　　要：目的探讨分析采用规范化治疗妊娠合并甲亢的临床疗效及对妊娠结局的影响作用。方法以本院2016年10月至2019年10月收治的80例妊娠合并甲亢患者为研究对象,根据患者意愿分为两组,将拒绝治疗的40例患者纳入对照组,进行规范化治疗的40例患者纳入观察组。统计并比两组患者的甲状腺功能相关指标(促甲状腺激素、总甲状腺素、游离甲状腺素、游离三碘甲状腺原氨酸、总三碘甲状腺原氨酸)、妊娠结局(阴道分娩、剖宫产、早产、流产)、围生儿的不良结局(早产儿、新生儿窒息、新生儿甲亢、胎儿畸形、新生儿体质量过低以及甲状腺危象)。结果治疗后观察组的促甲状腺激素检测水平明显高于对照组(P<0.05);总甲状腺素、游离甲状腺素、游离三碘甲状腺原氨酸和总三碘甲状腺原氨酸水平均明显低于对照组(P<0.05);观察组的妊娠结局相对优于对照组,其中观察组阴道分娩率为50.00%(20/40),对照组阴道分娩率为25.00%(10/40),差异具有统计学意义(P<0.05)。观察组围生儿的不良结局发生率为5%,低于对照组22.5%,组间差异具有统计学意义(P<0.05)。结论对于妊娠合并甲亢患者采用规范化治疗干预能够有效控制甲状腺各项临床指标检测水平,有利于改善妊娠结局,并利于降低围生儿发生不良结局的风险。Objective To explore and analyze the clinical effect of standardized treatment of pregnancy with hyperthyroidism and its effect on pregnancy outcome.Methods A total of 80 pregnant patients with hyperthyroidism admitted to our hospital from October 2016 to October 2019 were selected as the research object.According to the patients'will,they were divided into two groups.40 patients who refused treatment were included in the control group,and 40 patients who received standardized treatment were included in the observation group.Thyroid function related indicators(thyrotropin,total thyroxine,free thyroxine,free triiodothyronine and total triiodothyronine),the pregnancy outcomes(vaginal delivery,cesarean section,premature delivery and abortion),adverse outcomes of perinatal infants(premature infants,neonatal asphyxia,hyperthyroidism,fetal malformation,neonatal underweight and thyroid crisis)were counted and compared between the two groups.Results After treatment for thyroid-stimulating hormone levels of observation group was obviously higher than that of refusing to accept the treatment of the control group,the total thyroxine and free thyroxine,free three iodine original amino acid and total thyroid iodine thyroid original amino acid levels were significantly lower than control group,compared with the normal reference value of the clinical indicators levels in observation group were significantly better than the control group,the difference was statistically significant(P<0.05).The pregnancy outcome of the observation group was relatively better than that of the control group.The vaginal delivery rate of the observation group was 50.00%(20/40),which was higher than that of the control group was 25.00%(10/40)),and the difference was statistically significant(P<0.05).The incidence of adverse outcomes of perinatal infants in the observation group was 5%,which was lower than that in the control group(22.5%),and the difference was statistically significant(P<0.05).Conclusion Standardized treatment intervention for pregnan

关 键 词：规范化治疗 妊娠合并甲亢 妊娠结局 影响作用 

分 类 号：R714.256[医药卫生—妇产科学] R581.1[医药卫生—临床医学]