丙基硫氧嘧啶联合碳酸锂治疗甲状腺功能亢进的疗效观察  

Observation on the Efficacy of Propyl Thiouracil Combined with Lithium Carbonate in the Treatment of Hyperthyroidism

作　　者：廉臻 LIAN Zhen(Department of Endocrinology,Dandong Hospital of Traditional Chinese Medicine,Dandong 118000,China)

机构地区：[1]丹东市中医院内分泌科,辽宁丹东118000

出　　处：《中国医药指南》2021年第31期67-69,共3页Guide of China Medicine

摘　　要：目的分析甲状腺功能亢进(简称“甲亢”),探讨丙基硫氧嘧啶联合碳酸锂治疗甲亢疾病的疗效。方法将2017年5月至2018年7月144例甲亢患者随机数字表法分为两组,即对照组与研究组,各72例。对照组仅采取丙基硫氧嘧啶治疗,研究组采取丙基硫氧嘧啶联合碳酸锂治疗。比较两组甲亢患者的治疗情况,包括两组患者治疗前后总三碘甲状腺原氮酸(TT_(3))、总甲状腺激素(TT_(4))、游离三碘甲状腺原氨酸(FT_(3))、游离甲状腺素(FT_(4))水平,以及临床疗效、不良反应发生情况。结果治疗后,研究组患者的TT_(3)为(1.71±0.52)ng/mL、TT_(4)为(9.22±1.53)μg/dL、FT_(3)为(2.84±0.73)ng/mL、FT_(4)为(1.06±0.36)μg/dL,对照组分别为(2.69±0.47)ng/mL、(12.63±2.42)μg/dL、(6.42±0.69)ng/mL、(2.38±0.55)μg/dL,比较具有统计学意义(P<0.05)。研究组的总有效率(93.06%)明显高于对照组(77.78%)(P<0.05);研究组患者中恶心呕吐以及手抖加重、头晕各2例,总发生率8.34%。对照组患者中恶心呕吐2例、手抖加重3例、头晕1例,总发生率8.34%。两组不良反应发生情况接近(P>0.05)。结论甲亢采用丙基硫氧嘧啶联合碳酸锂治疗的效果明显优于单纯丙基硫氧嘧啶治疗,促进甲状腺激素水平恢复正常,用药安全性高。Objective To analyze hyperthyroidism(referred to as"hyperthyroidism")and explore the efficacy of propylthiouracil combined with lithium carbonate in the treatment of hyperthyroidism.Methods From May 2017 to July 2018,144 patients with hyperthyroidism were randomly divided into two groups,namely the control group and the study group,with 72 cases in each.The control group was only treated with propylthiouracil,and the study group was treated with propylthiouracil combined with lithium carbonate.The treatment of hyperthyroidism between the two groups was compared,including total triiodothyronine(TT_(3)),total thyroid hormone(TT_(4)),and free triiodothyronine(FT_(3)),free thyroxine(FT_(4))levels before and after treatment,clinical efficacy,and occurrence of adverse reactions.Results After treatment,TT_(3) of patients in the study group was(1.71±0.52)ng/mL,TT_(4) was(9.22±1.53)μg/dL,FT_(3) was(2.84±0.73)ng/mL,and FT_(4) was(1.06±0.36)μg/dL,the control group were(2.69±0.47)ng/mL,(12.63±2.42)μg/dL,(6.42±0.69)ng/mL,(2.38±0.55)μg/dL,the comparison was statistically significant(P<0.05).The total effective rate of the study group(93.06%)was significantly higher than that of the control group(77.78%)(P<0.05).In the study group,there were 2 cases of dizziness in each case,with a total incidence of 8.34%.In the control group,there were 2 cases of nausea and vomiting,3 cases of increased hand tremor,and 1 case of dizziness.The total incidence was 8.34%.The incidence of adverse reactions in the two groups was similar(P>0.05).Conclusion The effect of propylthiouracil combined with lithium carbonate in the treatment of hyperthyroidism is significantly better than that of propylthiouracil alone,promotes the return of thyroid hormone levels,and has high drug safety.

关 键 词：丙基硫氧嘧啶 碳酸锂 甲亢 治疗效果 不良反应 激素水平 

分 类 号：R581.1[医药卫生—内分泌]