参芪消脂方对ICR肥胖小鼠食欲的影响  

Effect of Shenqi Xiaozhi Recipe on appetite of ICR obese mice

作　　者：刘应科[1] 任昕昕 李天鑫 杨晔[1] 王秋莉[1] 张辰[1] LIU Yingke;REN Xinxin;LI Tianxin;YANG Ye;WANG Qiuli;ZHANG Chen(Department of Pediatric,Beijing Hepingli Hospital,Beijing,100013,China;the First Clinical Medical College,Beijing University of Chinese Medicine,Beijing,100029,China)

机构地区：[1]北京市和平里医院儿科,北京100013 [2]北京中医药大学第一临床医学院,北京100029

出　　处：《中国医药导报》2021年第28期44-47,共4页China Medical Herald

基　　金：国家中医药管理局全国老中医药专家学术经验传承项目。

摘　　要：目的研究参芪消脂方对ICR肥胖小鼠食欲的影响。方法取50只雄性SPF级ICR小鼠(鼠龄8周),体重(250±10)g,采用随机数字表法抽取8只作为正常组。其中正常组予普通饲料,其他给予高脂喂养。饲养12周后,大于正常组体重10%提示造模成功,按编号顺序取8只为模型组,8只为给药组。治疗组予参芪消脂方灌胃干预,另两组予蒸馏水灌胃干预,给药体积为0.2 ml/10 g。各组均灌胃12周,每天灌胃1次。在灌胃6周、12周时检测三组体脂量、体重及进食量。结果与模型组比较,给药组灌胃6周及12周进食量明显下降,差异有统计学意义(P<0.05)。与正常组比较,模型组灌胃12周后体重净增加显著增高,差异有统计学意义(P<0.05);与模型组比较,给药组灌胃6周及12周体重净增加均显著降低,差异有统计学意义(P<0.05)。模型组与给药组灌胃12周体重净增加与灌胃6周比较,差异有统计学意义(P<0.05)。与正常组比较,模型组灌胃6周及12周体脂比增加,差异有统计学意义(P<0.05)。灌胃12周,模型组体脂比高于灌胃6周,差异有统计学意义(P<0.05)。结论参芪消脂方可以降低ICR肥胖小鼠的食欲,并一定程度上改善体重。Objective To study the effect of Shenqi Xiaozhi Recipe on the appetite of ICR obese mice.Methods A total of 50 male SPF grade ICR mice(eight weeks old)were took,all weighing(250±10)g,and random number table method was used to select eight mice as normal group.The normal group was given normal feed,and the others were given high-fat feeding.After 12 weeks of administration,10%of the body weight greater than the normal group indicated that the model was successful.In order of numbering,eight animals were selected as the model group and eight as the drug group.The drug group was given Shenqi Xiaozhi Recipe by gavage intervention,and the other two groups were given distilled water gavage intervention,the administration volume was 0.2 ml/10 g.All groups were given intragastric administration for 12 weeks,once a day.At 6 and 12 weeks of administration,the body fat,weight and food intake of three groups were measured.Results Compared with the model group,the food intake of the drug group at 6 and 12 weeks of administration decreased significantly,and the differences were statistically significant(P<0.05).Compared with the normal group,the net weight gain of the model group increased significantly after 12 weeks of administration,and the difference was statistically significant(P<0.05);compared with the model group,the net weight gain of the drug group at 6 and 12 weeks of administration were significantly reduced,and the differences were statistically significant(P<0.05).There was a statistically significant difference in the net weight gain between the model group and the administration group after 12 weeks of administration and 6 weeks of administration(P<0.05).Compared with the normal group,the body fat ratio of the model group increased at 6 and 12 weeks after administration,and the differences were statistically significant(P<0.05).After 12 weeks of administration,the body fat ratio of the model group was higher than that of six weeks of administration,and the difference was statistically significant(P<0.05).Concl

关 键 词：参芪消脂方 单纯型肥胖症 食欲 脂质代谢 

分 类 号：R589.2[医药卫生—内分泌]