芜湖市乙肝免疫球蛋白与乙肝疫苗联合免疫阻断乙肝病毒母婴传播效果评价  

Evaluation of combined immunologic effect of hepatitis B immunoglobulin and hepatitis B vaccine to block mother-to-child transmission of hepatitis B in Wuhu City

作　　者：吴炜林 王睿 王润 芮婷婷 曹臻 陶庆 WU Wei-lin;WANG Rui;WANG Run;RUI Ting-ting;CAO Zhen;TAO Qing(Wuhu Maternal and Child Health and Family Planning Service Center,Anhui 241000,China)

机构地区：[1]芜湖市妇幼保健计划生育服务中心,安徽241000

出　　处：《安徽预防医学杂志》2021年第5期374-376,398,共4页Anhui Journal of Preventive Medicine

基　　金：2017年安徽省妇幼健康科研课题(编号:7FY008)。

摘　　要：目的观察芜湖市乙肝免疫球蛋白(HBIG)与乙肝疫苗(HepB)联合免疫阻断乙型肝炎病毒传播效果。方法收集芜湖市2017年4月至2019年12月319例乙型肝炎病毒表面抗原(HBsAg)阳性孕产妇所生婴儿血清,所有婴儿在分娩后24 h内均注射100国际单位(IU)HBIG,并按照"0-1-6"接种程序完成3剂次乙肝疫苗接种,在完成第3剂次乙肝疫苗接种后1~6个月,即儿童7月龄至12月龄期间召回检测"乙肝两对半",评估免疫效果。结果婴儿HBsAg阴性率98.43%;婴儿HBsAb阳性率98.12%,母亲HBeAg阳性组与阴性组的婴儿HBsAg阴性率差异均有统计学意义(Fisher’确切概率P=0.005);婴儿HBsAb阳性率差异有统计学意义(χ^(2)_(校正)=6.079,P=0.014)。结论 HBIG与HepB联合免疫阻断乙肝病毒母婴传播效果显著。Objective To observe the effect of hepatitis B immunoglobulin(HBIG)combined with hepatitis B vaccine(HepB)on blocking the transmission of hepatitis B virus in Wuhu City.Methods Infant Serum samples from 319 pregnant women with positive hepatitis B virus surface antigen(HBsAg)were collected from April 2017 to December 2019 in Wuhu City.All infants were injected with 100 international units(IU)HBIG in 24 h after delivery,and 3 doses of hepatitis B vaccine were received according to the"0-1-6"vaccination procedure.During the 1~6 months after the completion of the third dose of hepatitis B vaccination,that is,when children were 7 month old to 12 month old,they would be recalled to detect hepatitis B to evaluate the immune effect.Results The negative rate of HBsAg in infants was 98.43%,and the positive rate of HBsAb in infants was 98.12%.There was significant difference in the negative rate of HBsAg in infants between the mother’s HBeAg positive group and the negative group(Fisher’exact probability P=0.005).There was significant difference in the positive rate of HBsAb in infants.Conclusion The combined immunization of HBIG and HepB has a significant effect in blocking mother-to-child transmission of hepatitis B.

关 键 词：乙肝免疫球蛋白 乙肝疫苗 乙肝病毒 母婴阻断传播 预防接种 免疫效果评估 

分 类 号：R174[医药卫生—妇幼卫生保健]